A comprehensive study of the enantioseparation of chiral drugs by cyclodextrin using capillary electrophoresis combined with theoretical approaches

	A comprehensive study of the enantioseparation of chiral drugs by cyclodextrin using capillary electrophoresis combined with theoretical approaches
	Li,Libo; Li,Xia; Luo,Quan; You,Tianyan
刊名	talanta
	2015
卷号	142 页码:28-34
关键词	MAGNETIC-RESONANCE-SPECTROSCOPY BETA-CYCLODEXTRIN RECOGNITION MECHANISM IONIC LIQUIDS SEPARATION ENANTIOMERS SELECTOR DERIVATIVES CD CE
通讯作者	luo,q
英文摘要	four chiral drugs were enantioseparated by native beta-cyclodextrin (beta-cd) and negatively charged carboxymethyl-beta-cyclodextrin (cm-beta-cd) using capillary electrophoresis coupled with electro-chemiluminescence detection (ce-ecl). using 50 mm ph 5.5 tris-h3po4 with 10 mm cm-beta-cd as a running buffer, high resolution efficiency could be obtained. with the help of isothermal titration calorimetry (itc), nuclear magnetic resonance (nmr) and molecular modeling, the chiral recognition mechanism was comprehensively investigated. thermodynamic parameters data from itc revealed that cm-beta-cd exhibited stronger binding affinity with analytes than beta-cd, and that the driving forces of cm-beta-cd responsible for chiral recognition were mainly electrostatic interactions between negatively charged cm-beta-cd and positively charged analytes. in addition, from both a macroscopic and microscopic point of view, the results of nmr and molecular modeling investigation adequately confirm the conclusion by comparing the stereochemical structures of complexes. combination of itc, nmr and molecular modeling techniques not only can assist ce to investigate the chiral discrimination mechanism, but also can predict and guide ce enantioseparation efficiency conversely. (c) 2015 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67905]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li,Libo,Li,Xia,Luo,Quan,et al. A comprehensive study of the enantioseparation of chiral drugs by cyclodextrin using capillary electrophoresis combined with theoretical approaches[J]. talanta,2015,142:28-34.
APA	Li,Libo,Li,Xia,Luo,Quan,&You,Tianyan.(2015).A comprehensive study of the enantioseparation of chiral drugs by cyclodextrin using capillary electrophoresis combined with theoretical approaches.talanta,142,28-34.
MLA	Li,Libo,et al."A comprehensive study of the enantioseparation of chiral drugs by cyclodextrin using capillary electrophoresis combined with theoretical approaches".talanta 142(2015):28-34.