G-quadruplex DNA/protoporphyrin IX-based synergistic platform for targeted photodynamic cancer therapy

	G-quadruplex DNA/protoporphyrin IX-based synergistic platform for targeted photodynamic cancer therapy
	Zhou,Zhixue; Li,Dan; Zhang,Libing; Wang,Erkang; Dong,Shaojun
刊名	talanta
	2015
卷号	134 页码:298-304
关键词	G-RICH OLIGONUCLEOTIDE ERYTHROLEUKEMIC CELLS TELOMERASE ACTIVITY AQUEOUS-SOLUTION DNA PORPHYRINS PROTOPORPHYRIN FLUORESCENCE DESTRUCTION EXPRESSION
通讯作者	wang,ek
英文摘要	photodynamic therapy (pdt) is an emerging technique to induce cancer cell death. however, the tumor specificity, cellular uptake and biodistribution of many photosensitizers urgently need to be improved. in this regard, we show here that the integrated nanoassemblies based on g-quadruplex dnas (gqds)/protoporphyrin ix (ppix) can serve as a synergistic platform for targeted high-performance pdt. in the nanoassemblies, gqds function as carriers of sensitiser ppix and confers the system cancer cell targeting ability. after nucleolin-mediated efficient binding and cellular uptake of gqds/ppix assemblies, the strong red fluorescence of gqds/ppix complex provides a powerful tool for biological imaging. moreover, the reactive oxygen species (ros) generated by gqds/ppix under light illumination can effectively kill cancer cells. the present approach is simply composed by dna and photosensitizers, thereby avoiding any complicated and time-consuming covalent modification or chemical labeling procedure. (c) 2014 published by elsevier b.v.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67902]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhou,Zhixue,Li,Dan,Zhang,Libing,et al. G-quadruplex DNA/protoporphyrin IX-based synergistic platform for targeted photodynamic cancer therapy[J]. talanta,2015,134:298-304.
APA	Zhou,Zhixue,Li,Dan,Zhang,Libing,Wang,Erkang,&Dong,Shaojun.(2015).G-quadruplex DNA/protoporphyrin IX-based synergistic platform for targeted photodynamic cancer therapy.talanta,134,298-304.
MLA	Zhou,Zhixue,et al."G-quadruplex DNA/protoporphyrin IX-based synergistic platform for targeted photodynamic cancer therapy".talanta 134(2015):298-304.