A polymer-(multifunctional single-drug) conjugate for combination therapy

	A polymer-(multifunctional single-drug) conjugate for combination therapy
	Zhou,Dongfang; He,Shasha; Cong,Yuwei; Xie,Zhigang; Chen,Xuesi; Jing,Xiabin; Huang,Yubin
刊名	journal of materials chemistry b
	2015
卷号	3 期号:24 页码:4913-4921
关键词	PLATINUM ANTICANCER COMPLEX OVARIAN-CARCINOMA CELLS POLYMER THERAPEUTICS CANCER-CHEMOTHERAPY DRUG-RESISTANCE DNA-DAMAGE ENHANCED PERMEABILITY CO-DELIVERY PRO-DRUG IN-VIVO
通讯作者	huang,yb
英文摘要	combination therapy based on polymer-drug conjugates is one of the exciting developments in polymeric drug delivery systems. a single polymer carrier with two or more drugs attached is advantageous because it provides a platform for synergistic agent action. to expand the concept of combination therapy using a single polymer-drug conjugate, we report a polymer-(multifunctional single-drug) conjugate strategy, in which three different drugs (platinum, azidyl radical and dmc) and two different types of therapies are rationally integrated and then conjugated to an amphiphilic block copolymer. when this polymer-(multifunctional single-drug) conjugate is internalized by cancer cells via endocytosis, the three integrated drugs are expected to be activated and execute therapeutic functions in a sequential fashion under extracellular (uva irradiation) and intracellular (endosomes/lysosomes) environments to amplify the signals of cancer treatment, especially in cisplatin-resistant cancer cells.
收录类别	SCI
语种	英语
WOS记录号	WOS:000355989200016
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65080]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhou,Dongfang,He,Shasha,Cong,Yuwei,et al. A polymer-(multifunctional single-drug) conjugate for combination therapy[J]. journal of materials chemistry b,2015,3(24):4913-4921.
APA	Zhou,Dongfang.,He,Shasha.,Cong,Yuwei.,Xie,Zhigang.,Chen,Xuesi.,...&Huang,Yubin.(2015).A polymer-(multifunctional single-drug) conjugate for combination therapy.journal of materials chemistry b,3(24),4913-4921.
MLA	Zhou,Dongfang,et al."A polymer-(multifunctional single-drug) conjugate for combination therapy".journal of materials chemistry b 3.24(2015):4913-4921.