Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase

	Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase
	Zhao, Xi-Run 1; Huo, Xiao-Kui 1; Dong, Pei-Pei 2,3; Wang, Chao 1; Huang, Shan-Shan 1; Zhang, Bao-Jing 1; Zhang, Hou-Li 1; Deng, Sa 1; Liu, Ke-Xin 1; Ma, Xiao-Chi 1,2
刊名	journal of natural products
	2015-08-01
卷号	78 期号:8 页码:1868-1876
英文摘要	twelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of ganoderma lucidum. the new compounds were lanostane nortriterpenoids with 27 carbons (1-5 and 8), lanostane nor-triterpenoids with 25 carbons (6 and 7), and lanostane triterpenoids (9-12) based on multiple spectroscopic data analysis, including hresims, 1d-nmr, 2d-nmr, and cd. compounds 1-5 were identified as rare nor-lanostanoids that contain a 17 beta-pentatomic lactone ring. compound 13, possessing a lactone ring, had been isolated previously. the p-glycoprotein (p-gp) inhibitory effects of compounds 1-21 were evaluated at a concentration of 20 mu m using an adriamycin (adm)-resistant human breast adenocarcinoma cell line (mcf-7/adr). compounds 1, 5, 18, and 20 and verapamil increased the accumulation of adm in mcf-7/adr cells approximately 3-fold when compared with the negative control. these data support the significant p-glycoprotein inhibitory activities of compounds 1, 5, 18, and 20. in silico docking analysis suggested these compounds had similar p-gp recognition mechanisms compared with those of verapamil (a classical inhibitor). furthermore, in an in vitro bioassay, compounds 2, 4, 5, 6, and 18 showed moderate inhibitory effects against alpha-glucosidase compared with those of the positive control acarbose.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	fruiting bodies ; fr karst ; intestinal-absorption ; c-30 terpenoids ; bitter c-27 ; in-vitro ; acid-f ; triterpenoids ; cells ; polysaccharides
收录类别	SCI
语种	英语
WOS记录号	WOS:000360773700009
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146511]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Coll Pharm, Key Lab Metab & Transport Liaoning, Dalian 116044, Peoples R China 2.Dalian Med Univ, Acad Integrat Med, Dalian 116044, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xi-Run,Huo, Xiao-Kui,Dong, Pei-Pei,et al. Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase[J]. journal of natural products,2015,78(8):1868-1876.
APA	Zhao, Xi-Run.,Huo, Xiao-Kui.,Dong, Pei-Pei.,Wang, Chao.,Huang, Shan-Shan.,...&Ma, Xiao-Chi.(2015).Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase.journal of natural products,78(8),1868-1876.
MLA	Zhao, Xi-Run,et al."Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase".journal of natural products 78.8(2015):1868-1876.