Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis

	Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
	Frei, Michelle S.1; Bilyard, Matthew K.1; Alanine, Thomas A.1; Galloway, Warren R. J. D.1; Stokes, Jamie E.1; Spring, David R.1,2
刊名	bioorganic & medicinal chemistry
	2015-06-01
卷号	23 期号:11 页码:2666-2679
关键词	Heterocycles Scaffold Metathesis Libraries Synthetic methodology
英文摘要	herein, we report on work towards the development of a new strategy for the synthesis of rare and biologically interesting indolizin-5(3h)-ones, which is based around the use of ring-closing metathesis to construct the carbocyclic ring system. this study has provided insights into the general stability of indolizin-5(3h)-ones and their tendency to exist as the tautomeric indolizin-5-ols. furthermore, this approach has allowed access to other novel structurally related compounds based around unusual 6,5-azabicyclic scaffolds, which are also difficult to generate using typical methods. the azabicyclic compounds synthesized in this study reside in attractive regions of heterocyclic chemical space that are underexploited in current drug and agrochemical discovery efforts. (c) 2014 elsevier ltd. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemistry & molecular biology ; chemistry, medicinal ; chemistry, organic
研究领域[WOS]	biochemistry & molecular biology ; pharmacology & pharmacy ; chemistry
关键词[WOS]	camptothecin ; heterocycles ; space
收录类别	SCI
语种	英语
WOS记录号	WOS:000354025700009
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146224]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Frei, Michelle S.,Bilyard, Matthew K.,Alanine, Thomas A.,et al. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis[J]. bioorganic & medicinal chemistry,2015,23(11):2666-2679.
APA	Frei, Michelle S.,Bilyard, Matthew K.,Alanine, Thomas A.,Galloway, Warren R. J. D.,Stokes, Jamie E.,&Spring, David R..(2015).Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis.bioorganic & medicinal chemistry,23(11),2666-2679.
MLA	Frei, Michelle S.,et al."Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis".bioorganic & medicinal chemistry 23.11(2015):2666-2679.