Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging

	Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging
	Zhang, Fei 1,2; Sun, Ting-Ting 1,2; Zhang, Yan 3,4; Li, Qiong 5,6; Chai, Chao 5,6; Lu, Li 5,6; Shen, Wen 5,6; Yang, Jun 3,4; He, Xi-Wen 1,2; Zhang, Yu-Kui 1,2,7
刊名	journal of materials chemistry b
	2014
卷号	2 期号:41 页码:7201-7209
英文摘要	magnetic quantum dots (mqds) are an important class of agents for fluorescence (fl)/magnetic resonance (mr) dual-modal imaging due to their excellent optical and magnetic properties. however, functional mqds prepared by a simple room-temperature route as fl/mr dual-modal imaging probes are lacking. herein, we report the fabrication of gd-doped cdte quantum dots (gd:cdte qds) as an agent for fl/mr dual-modality imaging. the as-designed qds with an ultrasmall particle size are synthesized by a facile one-pot aqueous synthesis approach at room temperature. they emit strong fluorescence at 640 nm with a quantum yield of 37% in water, and they have a high longitudinal relaxation rate (r(1)) value of 3.27 mm(-1) s(-1). with the further conjugation of folic acid, the gd:cdte qds can successfully label live hepg2 cells for targeted cellular imaging and present no evidence of cellular toxicity up to the concentration of 0.5 mg ml(-1). they have been employed as a suitable contrast agent successfully for tumor-targeted fl/mr dual-modal imaging in a mouse model.
WOS标题词	science & technology ; technology
类目[WOS]	materials science, biomaterials
研究领域[WOS]	materials science
关键词[WOS]	ray computed-tomography ; in-vivo ; semiconductor nanocrystals ; gold nanoclusters ; contrast agents ; nanoparticles ; nanoprobes ; cancer ; probes ; photoluminescence
收录类别	SCI
语种	英语
WOS记录号	WOS:000342763700014
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145886]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China 3.Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 4.Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China 5.Tianjin Med Univ, Tianjin First Cent Hosp, Cent Clin Coll, Tianjin 300192, Peoples R China 6.Tianjin First Cent Hosp, Dept Radiol, Tianjin 300192, Peoples R China 7.Chinese Acad Sci, Natl Chromatog Res & Anal Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fei,Sun, Ting-Ting,Zhang, Yan,et al. Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging[J]. journal of materials chemistry b,2014,2(41):7201-7209.
APA	Zhang, Fei.,Sun, Ting-Ting.,Zhang, Yan.,Li, Qiong.,Chai, Chao.,...&Li, Wen-You.(2014).Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging.journal of materials chemistry b,2(41),7201-7209.
MLA	Zhang, Fei,et al."Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging".journal of materials chemistry b 2.41(2014):7201-7209.