Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines

	Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines
	Cai, Xian-Feng 1,2; Guo, Ran-Ning 1; Chen, Mu-Wang 1; Shi, Lei 1; Zhou, Yong-Gui 1
刊名	chemistry-a european journal
	2014-06-10
卷号	20 期号:24 页码:7245-7248
关键词	aromatic amines asymmetric hydrogenation chirality exocyclic amines
英文摘要	asymmetric hydrogenation of aromatic quinolin-3-amines was successfully developed with up to 94% enantiomeric excess (ee). introduction of the phthaloyl moiety to the amino group is crucial to eliminate the inhibition effect caused by the substrate and product, to activate the aromatic ring, and to improve the diastereo-selectivity. this new methodology provides direct and facile access to chiral exocyclic amines. notably, this report is the first on the highly enantioselective hydrogenation of aromatic amines.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	iridium-catalyzed hydrogenation ; 2 contiguous stereocenters ; enantioselective hydrogenation ; heteroaromatic-compounds ; isoquinolinium salts ; facile access ; quinolines ; quinoxalines ; reduction ; efficient
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000337617500008
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145735]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Dept Chem, Dalian 116012, Peoples R China
推荐引用方式 GB/T 7714	Cai, Xian-Feng,Guo, Ran-Ning,Chen, Mu-Wang,et al. Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines[J]. chemistry-a european journal,2014,20(24):7245-7248.
APA	Cai, Xian-Feng,Guo, Ran-Ning,Chen, Mu-Wang,Shi, Lei,&Zhou, Yong-Gui.(2014).Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines.chemistry-a european journal,20(24),7245-7248.
MLA	Cai, Xian-Feng,et al."Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines".chemistry-a european journal 20.24(2014):7245-7248.