Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging

	Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging
	Wu, Hao 1,2; Zhao, Haidong 3; Song, Xiaojie 1,2; Li, Shen 1,2; Ma, Xiaojun 1; Tan, Mingqian 1
刊名	journal of materials chemistry b
	2014-08-28
卷号	2 期号:32 页码:5302-5308
通讯作者	马小军 ; 谭明乾
英文摘要	fabrication of near-infrared (nir) fluorescent nanoprobes (nps) has drawn great attention due to their potential as highly sensitive optical probes for in vivo tumor molecular imaging. herein, a facile strategy has been reported for the preparation of ultrasmall (<20 nm) indocyanine green (icg)-containing nir fluorescent nps using self-assembly chemistry between folate (fa) modified water-soluble chitosan (wcs) and icg. the icg-containing nps exhibit characteristics of crystalline solid, good photostability, low cytotoxicity and high tumor targeting ability for in vitro cell imaging. we also explored this system for in vivo tumor molecular imaging. significant tumor accumulation was observed for both in vitro and in vivo tumor imaging in hela tumor cell imaging and xenograft-bearing mice model (2 mu mol kg(-1) at 48 and 72 h time points). the availability of these self-assembled nir nps provides a convenient tool for tumor imaging and detection.
学科主题	物理化学
WOS标题词	science & technology ; technology
类目[WOS]	materials science, biomaterials
研究领域[WOS]	materials science
关键词[WOS]	indocyanine-green ; silica nanoparticles ; contrast agent ; in-vitro ; chitosan ; cancer ; biodistribution ; micelles ; surgery ; systems
收录类别	SCI
语种	英语
WOS记录号	WOS:000340076100020
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/144519]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wu, Hao,Zhao, Haidong,Song, Xiaojie,et al. Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging[J]. journal of materials chemistry b,2014,2(32):5302-5308.
APA	Wu, Hao,Zhao, Haidong,Song, Xiaojie,Li, Shen,Ma, Xiaojun,&Tan, Mingqian.(2014).Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging.journal of materials chemistry b,2(32),5302-5308.
MLA	Wu, Hao,et al."Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging".journal of materials chemistry b 2.32(2014):5302-5308.