A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

	A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells
	Qiao, Qinglong 1,2; Zhao, Miao 2; Lang, Haijing 2; Mao, Deqi 1,2; Cui, Jingnan 1; Xu, Zhaochao 1,2
刊名	rsc advances
	2014
卷号	4 期号:49 页码:25790-25794
通讯作者	徐兆超 ; 崔京南
英文摘要	hydrogen sulfide (h2s) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. h2s can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. in this study, we developed a lysosome-targetable fluorescent probe for the recognition of h2s with considerable fluorescence enhancement. through introducing a lysosome-targetable group 4-(2aminoethyl)-morpholine into the h2s probe n-imide termus of 4-azide-1,8-naphthalimide, the new compound lyso-afp can recognize h2s in lysosomes. this probe emerges as a more biocompatible analysis tool with low poison by-product than reported h2s fluorescent probes.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	2-photon probe ; live cells ; zinc ; ph ; activation ; mechanisms ; signals ; sensors ; tumors ; zn2+
收录类别	SCI
语种	英语
WOS记录号	WOS:000338434500038
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/143918]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Qinglong,Zhao, Miao,Lang, Haijing,et al. A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J]. rsc advances,2014,4(49):25790-25794.
APA	Qiao, Qinglong,Zhao, Miao,Lang, Haijing,Mao, Deqi,Cui, Jingnan,&Xu, Zhaochao.(2014).A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells.rsc advances,4(49),25790-25794.
MLA	Qiao, Qinglong,et al."A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells".rsc advances 4.49(2014):25790-25794.