Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines
	Chen FF(陈方方)1,2; Jie XY(解笑瑜)1,2; Shi YP(师彦平)1
刊名	Journal of Chromatography A
	2012
卷号	1252 页码:8-14
关键词	Magnetic molecularly imprinted polymers Rhaponticin Chinese patent medicines
ISSN号	0021-9673
通讯作者	师彦平
英文摘要	The magnetic molecularly imprinted polymers (MMIPs) had been synthesized for the selective extraction and clean-up of rhaponticin in Chinese patent medicines (CPM). The MMIPs were prepared via suspension polymerization, using Fe₃O₄ as magnetically component, rhaponticin as template molecule, acrylamide (AM) as functional monomers, styrene (St) as copolymer monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linker in dimethyl sulfoxide porogen. The obtained MMIPs were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). High performance liquid chromatography (HPLC) was used for analysis the target analytes. The polymers were evaluated further by batch rebinding experiments. From the derived Freundlich isotherm (FI) equation their binding capacity and binding strength were determined. Structurally similar compound resveratrol and a reference compound kirenol were used for investing the selective recognition capability of MMIPs. The MMIPs were used as sorbents for selective pre-concentration of rhaponticin from CPM samples. The contents of rhaponticin for the four CPM samples were found to be 11.84, 3.35, 4.47, and 7.57 μg g⁻¹, respectively, and the recoveries of spiked samples ranged from 77.82% to 91.00%. The prepared MMIPs could be applied to selectively pre-concentrate and determine rhaponticin in CPM samples.
学科主题	分析化学与药物化学
收录类别	SCI
资助信息	National Natural Science Foundation of China (no. 21075127;20875095)
语种	英语
WOS记录号	WOS:000307627300002
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/19568]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
作者单位	1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Chen FF,Jie XY,Shi YP. Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines[J]. Journal of Chromatography A,2012,1252:8-14.
APA	Chen FF,Jie XY,&Shi YP.(2012).Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines.Journal of Chromatography A,1252,8-14.
MLA	Chen FF,et al."Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines".Journal of Chromatography A 1252(2012):8-14.