Competitive binding-accelerated insulin release from a polypeptide nanogel for potential therapy of diabetes

	Competitive binding-accelerated insulin release from a polypeptide nanogel for potential therapy of diabetes
	Zhao,Li; Xiao,Chunsheng; Ding,Jianxun; Zhuang,Xiuli; Gai,Guangqing; Wang,Liyan; Chen,Xuesi
刊名	polymer chemistry
	2015
卷号	6 期号:20 页码:3807-3815
关键词	RESPONSIVE CONTROLLED-RELEASE REGULATED DRUG-DELIVERY PHENYLBORONIC ACID MESOPOROUS SILICA PHYSIOLOGICAL PH IN-VIVO TRIGGERED RELEASE GLUCOSE-OXIDASE CONCANAVALIN-A ORAL INSULIN
通讯作者	chen,xs
英文摘要	a kind of glucose-sensitive polypeptide nanogel was prepared via a two-step procedure. first, methoxy poly(ethylene glycol)-block-poly(gamma-benzyl-l-glutamate-co-(gamma-propargyl-l-glutamate-graft-glucose) (mpeg-b-p(blg-co-(plg-g-glu))) was synthesized by clicking 2'-azidoethyl-o-alpha-d-glucopyranoside to the plg unit in mpeg-b-p(blg-co-plg), which was synthesized by the ring-opening polymerization (rop) of gamma-benzyl-l-glutamate n-carboxyanhydride and gamma-propargyl-l-glutamate n-carboxyanhydride with mpeg-nh2 as the macroinitiator. the novel nanogel was subsequently prepared by cross-linking the glucose moieties through adipoylamidophenylboronic acid (aapba). the formation of the nanogel, i.e. the successful incorporation of phenylboronic acid (pba) in the core, was systematically verified. the resultant nanogel showed a remarkable glucose-sensitivity in phosphate-buffered saline (pbs). thus, insulin as a model drug was loaded into the glucose-sensitive polypeptide nanogel. the in vitro drug release profiles revealed that the release of insulin from the nanogel could be triggered by the presence of glucose through a competitive binding mechanism with the conjugated glucose. in detail, a faster release rate and a larger amount of released insulin were observed by the increased glucose concentration in pbs, which confirmed the potential application of the nanogel. furthermore, the excellent cytocompatibility and hemocompatibility of the nanogel were demonstrated. therefore, the biocompatible nanogel with an intelligent capacity for glucose-accelerated payload release should be promising for applications in diabetes treatment.
收录类别	SCI
语种	英语
WOS记录号	WOS:000354410300009
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64861]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhao,Li,Xiao,Chunsheng,Ding,Jianxun,et al. Competitive binding-accelerated insulin release from a polypeptide nanogel for potential therapy of diabetes[J]. polymer chemistry,2015,6(20):3807-3815.
APA	Zhao,Li.,Xiao,Chunsheng.,Ding,Jianxun.,Zhuang,Xiuli.,Gai,Guangqing.,...&Chen,Xuesi.(2015).Competitive binding-accelerated insulin release from a polypeptide nanogel for potential therapy of diabetes.polymer chemistry,6(20),3807-3815.
MLA	Zhao,Li,et al."Competitive binding-accelerated insulin release from a polypeptide nanogel for potential therapy of diabetes".polymer chemistry 6.20(2015):3807-3815.