Facile Preparation of Doxorubicin-Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy

	Facile Preparation of Doxorubicin-Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy
	Liu,Fuyao; He,Xiuxia; Lei,Zhen; Liu,Liang; Zhang,Junping; You,Hongpeng; Zhang,Huimao; Wang,Zhenxin
刊名	advanced healthcare materials
	2015
卷号	4 期号:4 页码:559-568
关键词	MUSSEL-INSPIRED POLYDOPAMINE CORE-SHELL NANOPARTICLES NANO-GRAPHENE OXIDE DRUG-DELIVERY MESOPOROUS SILICA PHOTOTHERMAL THERAPY CARBON NANOTUBES CANCER-THERAPY UPCONVERTING NANOPARTICLES PHOTODYNAMIC THERAPY
通讯作者	zhang,hm
英文摘要	the development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. here, a facile methodology is developed to construct a multifunctional nanotheranostic that gathers five functions, upconversion luminescence (ucl) imaging, t-1-weighted magnetic resonance imaging (mri), x-ray computed tomography (ct) imaging, photothermal therapy (ptt), and chemotherapy, into one single nanoprobe (named as ucnp@pda(5)-peg-dox). for generating the ucnp@pda(5)-peg-dox, a near-infrared light (nir)-absorbing polydopamine (pda) shell is directly coated on oleic-acid-capped -nagdf4:yb3+,er3+@-nagdf4 upconverting nanoparticle (ucnp) core for the first time to form monodisperse, ultrastable, and noncytotoxic core-shell-structured nanosphere via water-in-oil microemulsion approach. when combined with 808 nm nir laser irradiation, the ucnp@pda(5)-peg-dox shows great synergistic interaction between ptt and the enhanced chemotherapy, resulting in completely eradicated mouse-bearing sw620 tumor without regrowth. in addition, leakage study, hemolysis assay, histology analysis, and blood biochemistry assay unambiguously reveal that the ucnp@pda(5)-peg has inappreciable cytotoxicity and negligible organ toxicity. the results provide explicit strategy for fabricating multifunctional nanoplatforms from the integration of ucnp with nir-absorbing polymers, important for developing multi-mode nanoprobes for biomedical applications.
收录类别	SCI
语种	英语
WOS记录号	WOS:000351225700011
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64817]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu,Fuyao,He,Xiuxia,Lei,Zhen,et al. Facile Preparation of Doxorubicin-Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy[J]. advanced healthcare materials,2015,4(4):559-568.
APA	Liu,Fuyao.,He,Xiuxia.,Lei,Zhen.,Liu,Liang.,Zhang,Junping.,...&Wang,Zhenxin.(2015).Facile Preparation of Doxorubicin-Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy.advanced healthcare materials,4(4),559-568.
MLA	Liu,Fuyao,et al."Facile Preparation of Doxorubicin-Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy".advanced healthcare materials 4.4(2015):559-568.