High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical applications

	High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical applications
	Cui,Haitao; Zhuang,Xiuli; He,Chaoliang; Wei,Yen; Chen,Xuesi
刊名	acta biomaterialia
	2015
卷号	11 期号:1 页码:183-190
关键词	THERMOSENSITIVE HYDROGELS IN-VITRO COPOLYMER COACERVATION CISPLATIN OLIGOMERS DELIVERY GELATION POLYMER ACID)
通讯作者	wei,y
英文摘要	in the pursuit of new strategies for the design and synthesis of high performance, physically associated hydrogels, dynamic materials formed through electrostatic interactions can serve as a powerful model. here, we introduce a convenient strategy to obtain biodegradable hydrogels from aba triblock ionic polypeptides formed by mixing poly(l-glutamic acid)-block-poly(ethylene glycol)-block-poly(l-glutamic acid) (pga-peg-pga) with poly(l-lysine)-block-poly(ethylene glycol)-block-poly(l-lysine) (pll-peg-pll). the hydrogels showed tunable physical properties, high strength and reversible response. the reactive function groups in the ionic blocks can conjugate with oppositely charged drugs or proteins and allow for further modification. these ionic aba triblock polyelectrolytes can also encapsulate intact cells without significantly compromising cell viability, suggesting that the hydrogels have excellent cytocompatibility. in vivo evaluation performed in rats with subcutaneous injection indicated that the gels were formed and degraded, and hematoxylin and eosin staining suggested good biocompatibility in vivo. in addition, these advantages, combined with the synthetic accessibility of the copolymer, make this cross-linking system a flexible and powerful new tool for the development of injectable hydrogels for biomedical applications. (c) 2014 acta materialia inc. published by elsevier ltd. all rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64799]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Cui,Haitao,Zhuang,Xiuli,He,Chaoliang,et al. High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical applications[J]. acta biomaterialia,2015,11(1):183-190.
APA	Cui,Haitao,Zhuang,Xiuli,He,Chaoliang,Wei,Yen,&Chen,Xuesi.(2015).High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical applications.acta biomaterialia,11(1),183-190.
MLA	Cui,Haitao,et al."High performance and reversible ionic polypeptide hydrogel based on charge-driven assembly for biomedical applications".acta biomaterialia 11.1(2015):183-190.