DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for MR-Responsive and Aptamer-Targeted Drug Delivery

	DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for MR-Responsive and Aptamer-Targeted Drug Delivery
	Zhang,Yuanxin; Hou,Zhiyao; Ge,Yakun; Deng,Kerong; Liu,Bei; Li,Xuejiao; Li,Quanshun; Cheng,Ziyong; Ma,Ping'an; Li,Chunxia
刊名	acs applied materials & interfaces
	2015
卷号	7 期号:37 页码:20696-20706
关键词	NEAR-INFRARED LIGHT CONTROLLED-RELEASE GOLD NANOPARTICLES SIGNALING PATHWAYS P-GLYCOPROTEIN QUANTUM DOTS IN-VITRO CURCUMIN CELLS THERAPY
通讯作者	li,cx
英文摘要	near-infrared light is an attractive stimulus due to its noninvasive and deep tissue penetration. particularly, nir light is utilized for cancer thermotherapy and on-demand release of drugs by the disruption of the delivery carriers. here we have prepared a novel nir-responsive dna-hybrid-gated nanocarrier based on mesoporous silica-coated cu1.8s nanoparticles. cu1.8s nanoparticles, possessing high photothermal conversion efficiency under a 980 nm laser, were chosen as photothermal agents. the mesoporous silica structure could be used for drug storage/delivery and modified with aptamer-modified gc-rich dna-helix as gatekeepers, drug vectors, and targeting ligand. simultaneously, the as-produced photothermal effect caused denaturation of dna double strands, which triggered the drug release of the dna-helix-loaded hydrophilic drug doxorubicin and mesopore-loaded hydrophobic drug curcumin, resulting in a synergistic therapeutic effect. the cu1.8s@msio(2) nanocomposites endocytosed by cancer cells through the aptamer-mediated mode are able to generate rational release of doxorubicin/curcumin under nir irradiation, strongly enhancing the synergistic growth-inhibitory effect of curcumin against doxorubicin in mcf-7 cells, which is associated with a strong mitochondrial-mediated cell apoptosis progression. the underlying mechanism of apoptosis showed a strong synergistic inhibitory effect both on the expression of bcl-2, bcl-xl, mcl-1, and upregulated caspase 3/9 activity and on the expression level of bak and bax. therefore, cu1.8s@msio(2) with efficient synergistic therapeutic efficiency is a potential multifunctional cancer therapy nanoplatform.
收录类别	SCI
语种	英语
WOS记录号	WOS:000361931600025
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64753]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang,Yuanxin,Hou,Zhiyao,Ge,Yakun,et al. DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for MR-Responsive and Aptamer-Targeted Drug Delivery[J]. acs applied materials & interfaces,2015,7(37):20696-20706.
APA	Zhang,Yuanxin.,Hou,Zhiyao.,Ge,Yakun.,Deng,Kerong.,Liu,Bei.,...&Li,Chunxia.(2015).DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for MR-Responsive and Aptamer-Targeted Drug Delivery.acs applied materials & interfaces,7(37),20696-20706.
MLA	Zhang,Yuanxin,et al."DNA-Hybrid-Gated Photothermal Mesoporous Silica Nanoparticles for MR-Responsive and Aptamer-Targeted Drug Delivery".acs applied materials & interfaces 7.37(2015):20696-20706.