Fabrication of Multifunctional SiO2@GN-Serum Composites for Chemo-Photothermal Synergistic Therapy

	Fabrication of Multifunctional SiO2@GN-Serum Composites for Chemo-Photothermal Synergistic Therapy
	Liu,Yuwei; Bai,Jing; Jia,Xiaodan; Jiang,Xiue; Guo,Zhuo
刊名	acs applied materials & interfaces
	2015
卷号	7 期号:1 页码:112-121
关键词	BOVINE SERUM-ALBUMIN DRUG-DELIVERY MESOPOROUS SILICA GRAPHENE OXIDE GOLD NANORODS CANCER-CELLS IN-VIVO NANOPARTICLES NANOCOMPOSITES RELEASE
通讯作者	jiang,xe
英文摘要	recently, the chemo-photothermal synergistic therapy has become a potential method for cancer treatment. herein, we developed a multifunctional nanomaterial for chemo-photothermal therapeutics based on silica and graphene core/shell structure (sio2@gn) because of the ability of gn to convert light energy into heat. serum protein was further modified onto the surface of gn (sio2@gn-serum) to improve the solubility and stability of gn-based nanoparticles in physiological conditions. the as-synthesized sio2@gn-serum nanoparticles (nps) have been revealed to have high photothermal conversion efficiency and stability, as well as high storage and release capacity for anticancer drug doxorubicin (sio2@gn-serum-dox). the therapeutic efficacy of sio2@gn-serum-dox has been evaluated in vitro and in vivo for cervical cancer therapy. in vitro cytotoxicity tests demonstrate that sio2@gn-serum nps have excellent biocompatibility. however, sio2@gn-serum-dox nps show higher cytotoxicity than sio2@gn-serum and free dox under irradiation with nir laser at 1.0 w/cm(2) for 5 min owing to both sio2@gn-serum-mediated photothermal ablation and cytotoxicity of light-triggered dox release. in mouse models, the tumor growth is significantly inhibited by chem-photothermal effect of sio2@gn-serum-dox. overall, compared with single chemotherapy or photothermal therapy, the combined treatment demonstrates better therapeutic efficacy. our results suggest a promising gn-based core/shell nanostructure for biomedical applications.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64735]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu,Yuwei,Bai,Jing,Jia,Xiaodan,et al. Fabrication of Multifunctional SiO2@GN-Serum Composites for Chemo-Photothermal Synergistic Therapy[J]. acs applied materials & interfaces,2015,7(1):112-121.
APA	Liu,Yuwei,Bai,Jing,Jia,Xiaodan,Jiang,Xiue,&Guo,Zhuo.(2015).Fabrication of Multifunctional SiO2@GN-Serum Composites for Chemo-Photothermal Synergistic Therapy.acs applied materials & interfaces,7(1),112-121.
MLA	Liu,Yuwei,et al."Fabrication of Multifunctional SiO2@GN-Serum Composites for Chemo-Photothermal Synergistic Therapy".acs applied materials & interfaces 7.1(2015):112-121.