Hierarchical Nanowire Arrays as Three-Dimensional Fractal Nanobiointerfaces for High Efficient Capture of Cancer Cells

	Hierarchical Nanowire Arrays as Three-Dimensional Fractal Nanobiointerfaces for High Efficient Capture of Cancer Cells
	Zhang, Feilong 1,3; Jiang, Yan 1,3; Liu, Xueli 1,3; Meng, Jingxin 2; Zhang, Pengchao 1,3; Liu, Hongliang 2; Yang, Gao 1,3; Li, Guannan 1,3; Jiang, Lei 2,3; Wan, Li-Jun 1,3
刊名	NANO LETTERS
	2016
卷号	16 期号:1 页码:766-772
关键词	Nanobiointerfaces nanostructures cell capture topographical interaction cyto-compatibility
英文摘要	A hierarchical assembled ITO nanowire array with both horizontal and vertical nanowire branches was fabricated as a new three-dimensional fractal nanobiointerface for efficient cancer cell capture. Comparing with ITO nanowire array without branches, this fractal nanobiointerface exhibited much higher efficiency (89% vs 67%) and specificity in capturing cancer cells and took shorter time (35 vs 45 min) to reach the maximal capture efficiency. As indicated by the immunofluorescent and ESEM images, this enhancement can be attributed to the improvement of topographical interaction between cells and the substrate. The introduction of horizontal and vertical nanowire branches makes the substrate topo graphically match better with cell filopodia and provides more binding sites for cell capture. The live/dead cell staining and proliferation experiments confirm that this fractal nanobiointerface displays excellent cyto-compatibility with an over 96% cell viability after capture. These results provide new insights and may open up opportunities in designing and engineering new cell-material interfaces for advanced biomedical applications.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29771]
专题	化学研究所_有机固体实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Ctr Excellence Nanosci, Lab Bioinspired Smart Interface Sci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Feilong,Jiang, Yan,Liu, Xueli,et al. Hierarchical Nanowire Arrays as Three-Dimensional Fractal Nanobiointerfaces for High Efficient Capture of Cancer Cells[J]. NANO LETTERS,2016,16(1):766-772.
APA	Zhang, Feilong.,Jiang, Yan.,Liu, Xueli.,Meng, Jingxin.,Zhang, Pengchao.,...&Wang, Shutao.(2016).Hierarchical Nanowire Arrays as Three-Dimensional Fractal Nanobiointerfaces for High Efficient Capture of Cancer Cells.NANO LETTERS,16(1),766-772.
MLA	Zhang, Feilong,et al."Hierarchical Nanowire Arrays as Three-Dimensional Fractal Nanobiointerfaces for High Efficient Capture of Cancer Cells".NANO LETTERS 16.1(2016):766-772.