Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal Antimicrobial Application

	Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal Antimicrobial Application
	Sun, Han 1; Yin, Bohan 1; Ma, Hongli 1; Yuan, Huanriang 2; Fu, Bin 1; Liu, Libing 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-11-18
卷号	7 期号:45 页码:25390-25395
关键词	polyfluorene quinoline QAG ROS multimodal antimicrobial activity
英文摘要	A new functional polyfluorene derivative containing quinoline skeleton and quarternary ammonium group (QAG) modified side chains (PFPQ) was synthesized and characterized. The multimodal antimicrobial effect toward Gram-negative E. coli was achieved by the dark toxicity resulting from the quinoline skeleton, QAG, and light toxicity resulting from reactive oxygen species (ROS) produced by the main backbone of PFPQ under white light. The mechanism of interaction between PFPQ and bacteria was also demonstrated. PFPQ bound to E. coli mainly through electrostatic interactions causing nearly 50% bacterial death in the absence of light irradiation, and the huge capability of PFPQ to generate ROS under white light opened another bactericidal mode. The killing efficiency was more than 99% upon relatively mild irradiation under white light (400-800 nm) with a light dose of 18 J center dot cm(-2). PFPQ with the incorporation of quinoline into the backbones will provide a new versatile strategy to achieve the multimodal antimicrobial effect to fight against resistant bacteria.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29298]
专题	化学研究所_有机固体实验室
作者单位	1.China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Sun, Han,Yin, Bohan,Ma, Hongli,et al. Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal Antimicrobial Application[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(45):25390-25395.
APA	Sun, Han,Yin, Bohan,Ma, Hongli,Yuan, Huanriang,Fu, Bin,&Liu, Libing.(2015).Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal Antimicrobial Application.ACS APPLIED MATERIALS & INTERFACES,7(45),25390-25395.
MLA	Sun, Han,et al."Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal Antimicrobial Application".ACS APPLIED MATERIALS & INTERFACES 7.45(2015):25390-25395.