Topographical Binding to Mucosa-Exposed Cancer Cells: Pollen-Mimetic Porous Microspheres with Tunable Pore Sizes

	Topographical Binding to Mucosa-Exposed Cancer Cells: Pollen-Mimetic Porous Microspheres with Tunable Pore Sizes
	Feng, Jiantao 1,3; Lin, Ling 2,4; Chen, Peipei 3; Hua, Wenda 3,5; Sun, Quanmei 3; Ao, Zhuo 3; Liu, Dongsheng 1; Jiang, Lei 4; Wang, Shutao 4; Han, Dong 3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-05-06
卷号	7 期号:17 页码:8961-8967
关键词	microsphere adhesive topographical binding mucosa cancer cell
英文摘要	Mucoadhesives have been perceived as an effective approach for targeting the mucosa-associated diseases, which relied on the adhesive molecules to enhance the specificity. Here, topographical binding is proposed based on the fabrication of surface pore size tunable pollen-mimetic microspheres with phase separation and electrospray technology. We proved that microspheres with large-pores (pore size of 1005 +/- 448 nm) were the excellent potential candidate for the mucoadhesives) as they not only possessed better adhesion ability, but also could topographically bind cervical cancer cells. Our methods of topographical binding offered a new way of designing the mucoadhesives for treating the mucosa-associated diseases.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28104]
专题	化学研究所_有机固体实验室
作者单位	1.Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China 2.State Ocean Adm, Inst Oceanog 3, Engn Res Ctr Marine Biol Resource Comprehens Util, Xiamen 361005, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China 5.Kunming Med Univ, Affiliated Hosp 1, Kunming 650032, Peoples R China
推荐引用方式 GB/T 7714	Feng, Jiantao,Lin, Ling,Chen, Peipei,et al. Topographical Binding to Mucosa-Exposed Cancer Cells: Pollen-Mimetic Porous Microspheres with Tunable Pore Sizes[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(17):8961-8967.
APA	Feng, Jiantao.,Lin, Ling.,Chen, Peipei.,Hua, Wenda.,Sun, Quanmei.,...&Han, Dong.(2015).Topographical Binding to Mucosa-Exposed Cancer Cells: Pollen-Mimetic Porous Microspheres with Tunable Pore Sizes.ACS APPLIED MATERIALS & INTERFACES,7(17),8961-8967.
MLA	Feng, Jiantao,et al."Topographical Binding to Mucosa-Exposed Cancer Cells: Pollen-Mimetic Porous Microspheres with Tunable Pore Sizes".ACS APPLIED MATERIALS & INTERFACES 7.17(2015):8961-8967.