Flow Synthesis of Biocompatible Fe3O4 Nanoparticles: Insight into the Effects of Residence Time, Fluid Velocity, and Tube Reactor Dimension on Particle Size Distribution

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	Flow Synthesis of Biocompatible Fe3O4 Nanoparticles: Insight into the Effects of Residence Time, Fluid Velocity, and Tube Reactor Dimension on Particle Size Distribution
	Jiao, Mingxia 1; Zeng, Jianfeng 2; Jing, Lihong 1; Liu, Chunyan 1; Gao, Mingyuan 1
刊名	CHEMISTRY OF MATERIALS
	2015-02-24
卷号	27 期号:4 页码:1299-1305
英文摘要	PEGylated Fe3O4 nanoparticles were prepared through flow synthesis upon the pyrolysis of ferric acetylacetonate (Fe(acac)(3)) in anisole at 250 degrees C under pressure of 33 bar, in the presence of a,?-dicarboxyl-terminated polyethylene glycol (HOOC-PEG-COOH) and oleylamine. In combination with theoretical analysis, the effects of linear velocity, residence time, and reactor dimension on particle size distribution were systematically investigated. In addition, the impact of Ostwald ripening on particle size distribution was also revealed. In particular, the impacts of monomer concentration distributions along both axial and radial directions of the tube reactor on the particle size distribution were carefully investigated. Under optimized conditions, PEGylated Fe3O4 nanoparticles with the relative standard deviation of particle size down to 10.6% were thus obtained. The resulting 4.6 nm particles exhibited excellent colloidal stability and high longitudinal relaxivity (r(1)) up to 11.1 mM(-1) center dot s(-1), which manifested the reliability of flow synthesis in preparing PEGylated Fe3O4 nanoparticles as contrast agents for magnetic resonance imaging applications.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28286]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Soochow Univ, Sch Radiat Med & Radiat Protect, Suzhou 215123, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Jiao, Mingxia,Zeng, Jianfeng,Jing, Lihong,et al. Flow Synthesis of Biocompatible Fe3O4 Nanoparticles: Insight into the Effects of Residence Time, Fluid Velocity, and Tube Reactor Dimension on Particle Size Distribution[J]. CHEMISTRY OF MATERIALS,2015,27(4):1299-1305.
APA	Jiao, Mingxia,Zeng, Jianfeng,Jing, Lihong,Liu, Chunyan,&Gao, Mingyuan.(2015).Flow Synthesis of Biocompatible Fe3O4 Nanoparticles: Insight into the Effects of Residence Time, Fluid Velocity, and Tube Reactor Dimension on Particle Size Distribution.CHEMISTRY OF MATERIALS,27(4),1299-1305.
MLA	Jiao, Mingxia,et al."Flow Synthesis of Biocompatible Fe3O4 Nanoparticles: Insight into the Effects of Residence Time, Fluid Velocity, and Tube Reactor Dimension on Particle Size Distribution".CHEMISTRY OF MATERIALS 27.4(2015):1299-1305.