DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives

	DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives
	Liu, Ying 1,2; Wang, Linlin 1; Zhou, Jin 1; Wu, Shangrong 1; Wei, Yongbiao 1; Chang, Ang 1; Liu, Xiangjun 1; Shangguan, Dihua 1
刊名	DYES AND PIGMENTS
	2015-10-01
卷号	121 页码:328-335
关键词	Quinacridone derivatives DNA G-quadruplexes Cell permeability Cellular localization Fluorescent probes
英文摘要	Quinacridone derivatives (QAs) are widely used in industrial colorant, chemical sensors and organic optoelectronic devices; however their biological applications are rarely reported. Here we describe the interaction of QAs with different DNA forms and cancer cells. Quinacridone and N,N'-bis(5-bromopentyl) quinacridone (QAB) selectively bind parallel G-quadruplex DNA through end-stacking. N,N'-bis(methylpiperazinylpentyl) quinacridone (QAP) and N,N'-bis(dimethyl-aminopentyl) quinacridone (QAT) strongly bind all DNA forms through hydrogen bonding and electrostatic interaction of the alkylamine side chains and DNA. Quinacridone does not enter living cells; QAB enters living cells and mainly locates in lysosome; QAP and QAT enter living cells and locate in whole cells, especially in nuclei through binding DNA. However, these QAs do not show significant cytotoxicity. These results suggest that side chains greatly affect the DNA interaction, cellular permeability and localization of QAs, and provide useful information for the design of DNA-binding drugs and fluorescent probes. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27716]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ying,Wang, Linlin,Zhou, Jin,et al. DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives[J]. DYES AND PIGMENTS,2015,121:328-335.
APA	Liu, Ying.,Wang, Linlin.,Zhou, Jin.,Wu, Shangrong.,Wei, Yongbiao.,...&Shangguan, Dihua.(2015).DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives.DYES AND PIGMENTS,121,328-335.
MLA	Liu, Ying,et al."DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives".DYES AND PIGMENTS 121(2015):328-335.