Chitosan-based mucosal adjuvants: Sunrise on the ocean

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	Chitosan-based mucosal adjuvants: Sunrise on the ocean
	Xia, Yufei 1,2; Fan, Qingze 1,2; Hao, Dongxia 1; Wu, Jie 1; Ma, Guanghui 1; Su, Zhiguo 1
刊名	VACCINE
	2015-11-04
卷号	33 期号:44 页码:5997-6010
关键词	Chitosan Adjuvant Mucosal immunity Marine drug Clinical application
ISSN号	0264-410X
英文摘要	Mucosal vaccination, which is shown to elicit systemic and mucosal immune responses, serves as a non-invasive and convenient alternative to parenteral administration, with stronger capability in combatting diseases at the site of entry. The exploration of potent mucosal adjuvants is emerging as a significant area, based on the continued necessity to amplify the immune responses to a wide array of antigens that are poorly immunogenic at the mucosal sites. As one of the inspirations from the ocean, chitosan-based mucosal adjuvants have been developed with unique advantages, such as, ability of mucosal adhesion, distinct trait of opening the junctions to allow the paracellular transport of antigen, good tolerability and biocompatibility, which guaranteed the great potential in capitalizing on their application in human clinical trials. In this review, the state of art of chitosan and its derivatives as mucosal adjuvants, including thermo-sensitive chitosan system as mucosal adjuvant that were newly developed by author's group, was described, as well as the clinical application perspective. After a brief introduction of mucosal adjuvants, chitosan and its derivatives as robust immune potentiator were discussed in detail and depth, in regard to the metabolism, safety profile, mode of actions and preclinical and clinical applications, which may shed light on the massive clinical application of chitosan as mucosal adjuvant. (C) 2015 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Immunology ; Medicine, Research & Experimental
研究领域[WOS]	Immunology ; Research & Experimental Medicine
关键词[WOS]	STREPTOCOCCUS-PNEUMONIAE INFECTION ; PARTICULATE VACCINE ADJUVANTS ; ACIDIC MAMMALIAN CHITINASE ; THERMAL-SENSITIVE HYDROGEL ; EPITHELIAL-CELLS CACO-2 ; IN-VITRO PERMEABILITY ; NASAL DRUG-DELIVERY ; INFLUENZA VACCINE ; DENDRITIC CELLS ; MOLECULAR-WEIGHT
收录类别	SCI
语种	英语
WOS记录号	WOS:000365365700016
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/19893]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xia, Yufei,Fan, Qingze,Hao, Dongxia,et al. Chitosan-based mucosal adjuvants: Sunrise on the ocean[J]. VACCINE,2015,33(44):5997-6010.
APA	Xia, Yufei,Fan, Qingze,Hao, Dongxia,Wu, Jie,Ma, Guanghui,&Su, Zhiguo.(2015).Chitosan-based mucosal adjuvants: Sunrise on the ocean.VACCINE,33(44),5997-6010.
MLA	Xia, Yufei,et al."Chitosan-based mucosal adjuvants: Sunrise on the ocean".VACCINE 33.44(2015):5997-6010.