An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases

CORC > 过程工程研究所 > 中国科学院过程工程研究所 > 生化工程国家重点实验室

	An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases
	Li, Ping 1,2; Nie, Yaling 1,2; Yu, Jingkai 1
刊名	PLOS ONE
	2015-11-17
卷号	10 期号:11 页码:143045
ISSN号	1932-6203
英文摘要	Groups of distinct but related diseases often share common symptoms, which suggest likely overlaps in underlying pathogenic mechanisms. Identifying the shared pathways and common factors among those disorders can be expected to deepen our understanding for them and help designing new treatment strategies effected on those diseases. Neurodegeneration diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), were taken as a case study in this research. Reported susceptibility genes for AD, PD and HD were collected and human protein-protein interaction network (hPPIN) was used to identify biological pathways related to neurodegeneration. 81 KEGG pathways were found to be correlated with neurodegenerative disorders. 36 out of the 81 are human disease pathways, and the remaining ones are involved in miscellaneous human functional pathways. Cancers and infectious diseases are two major subclasses within the disease group. Apoptosis is one of the most significant functional pathways. Most of those pathways found here are actually consistent with prior knowledge of neurodegenerative diseases except two cell communication pathways: adherens and tight junctions. Gene expression analysis showed a high probability that the two pathways were related to neurodegenerative diseases. A combination of common susceptibility genes and hPPIN is an effective method to study shared pathways involved in a group of closely related disorders. Common modules, which might play a bridging role in linking neurodegenerative disorders and the enriched pathways, were identified by clustering analysis. The identified shared pathways and common modules can be expected to yield clues for effective target discovery efforts on neurodegeneration.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; CELL-DEATH ; HUNTINGTONS-DISEASE ; GENE-EXPRESSION ; NERVOUS-SYSTEM ; MOTOR SYMPTOMS ; UPDATE ; MODEL ; BRAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000365153400033
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/19859]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Ping,Nie, Yaling,Yu, Jingkai. An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases[J]. PLOS ONE,2015,10(11):143045.
APA	Li, Ping,Nie, Yaling,&Yu, Jingkai.(2015).An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases.PLOS ONE,10(11),143045.
MLA	Li, Ping,et al."An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases".PLOS ONE 10.11(2015):143045.