pH-Responsive Cyanine-Grafted Graphene Oxide for Fluorescence Resonance Energy Transfer-Enhanced Photothermal Therapy

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 张智军团队

	pH-Responsive Cyanine-Grafted Graphene Oxide for Fluorescence Resonance Energy Transfer-Enhanced Photothermal Therapy
	Guo, M; Huang, J(黄洁); Deng, YB; Shen, H(沈贺); Ma, YF(马宇飞); Zhang, MX(张萌欣); Zhu, AJ; Li, YL; Hui, H; Wang, YY
刊名	ADVANCED FUNCTIONAL MATERIALS
	2015
卷号	25 期号:1 页码:9
通讯作者	Guo, M
英文摘要	Stimuli-responsive anticancer agents are of particular interest in the field of cancer therapy. Nevertheless, so far stimuli-responsive photothermal agents have been explored with limited success for cancer photothermal therapy (PTT). In this work, as a proof-of-concept, a pH-responsive photothermal nanoconjugate for enhanced PTT efficacy, in which graphene oxide (GO) with broad NIR absorbance and effective photothermal conversion efficiency is selected as a typical model receptor of fluorescence resonance energy transfer (FRET), and grafted cyanine dye (e.g., Cypate) acts as the donor of near-infrared fluorescence (NIRF), is reported for the first time. The conjugate of Cypate-grafted GO exhibits different conformations in aqueous solutions at various pH, which can trigger pH-dependent FRET effect between GO and Cypate and thus induce pH-responsive photothermal effect of GO-Cypate. GO-Cypate exhibits severe cell damage owing to the enhanced photothermal effect in lysosomes, and thus generate synergistic PTT efficacy with tumor ablation upon photoirradiation after a single-dose intravenous injection. The photothermal nanoconjugate with broad NIR absorbance as the effective receptor of FRET can smartly convert emitted NIRF energy from donor cyanine dye into additional photothermal effect for improving PTT. These results suggest that the smart nanoconjugate can act as a promising stimuli-responsive photothermal nanoplatform for cancer therapy.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/3448]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队
推荐引用方式 GB/T 7714	Guo, M,Huang, J,Deng, YB,et al. pH-Responsive Cyanine-Grafted Graphene Oxide for Fluorescence Resonance Energy Transfer-Enhanced Photothermal Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(1):9.
APA	Guo, M.,Huang, J.,Deng, YB.,Shen, H.,Ma, YF.,...&Chen, HB.(2015).pH-Responsive Cyanine-Grafted Graphene Oxide for Fluorescence Resonance Energy Transfer-Enhanced Photothermal Therapy.ADVANCED FUNCTIONAL MATERIALS,25(1),9.
MLA	Guo, M,et al."pH-Responsive Cyanine-Grafted Graphene Oxide for Fluorescence Resonance Energy Transfer-Enhanced Photothermal Therapy".ADVANCED FUNCTIONAL MATERIALS 25.1(2015):9.