Synthesis of Gold Nanorods and Their Functionalization with Bovine Serum Albumin for Optical Hyperthermia

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 张智军团队

	Synthesis of Gold Nanorods and Their Functionalization with Bovine Serum Albumin for Optical Hyperthermia
	Zhang ZJ(张智军)
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2014-08
卷号	10 期号:8 页码:1440-1449
关键词	old Nanorods Hydroquinone NIR Hyperthermia Bovine Serum Albumin
通讯作者	Ju, SH
英文摘要	Although gold nanorods (GNRs) have been investigated extensively for optical hyperthermia therapies, the synthesis of rods is far from ideal. In this report, we optimized the synthesis of gold nanorods using hydroquinone as a reducing agent. Compared with the GNRs prepared by traditional ways, the as-synthesized rods have a flexibly tunable size and wider range of longitudinal surface plasmon resonance (LSPR). Furthermore, a series of small-length gold nanorods with length ranging from 30 to 90 nm were synthesized and they are more suitable for in vivo biomedical applications. Finally, we exploited a convenient approach for preparing water-soluble GNRs with less toxicity, better dispersion and flexible functionalization by exchanging hexadecyltrimethylammonium bromide (CTAB) on the surface of the rods with carboxylated bovine serum albumin (BSA) derivative, the BSA modified GNRs showed significant anticancer efficacy through near infrared (NIR) hyperthermia. We believe that the as-prepared gold nanorods will find promising applications in biomedical fields, especially in cancer therapy.
收录类别	SCI
语种	英语
WOS记录号	WOS:000334414000004
公开日期	2014-12-02
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/1639]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队
推荐引用方式 GB/T 7714	Zhang ZJ. Synthesis of Gold Nanorods and Their Functionalization with Bovine Serum Albumin for Optical Hyperthermia[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(8):1440-1449.
APA	Zhang ZJ.(2014).Synthesis of Gold Nanorods and Their Functionalization with Bovine Serum Albumin for Optical Hyperthermia.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,10(8),1440-1449.
MLA	Zhang ZJ."Synthesis of Gold Nanorods and Their Functionalization with Bovine Serum Albumin for Optical Hyperthermia".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 10.8(2014):1440-1449.