Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 王强斌团队

	Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform
	Hu, F(胡峰); Li, CY(李春炎); Zhang, YJ(张叶俊); Wang, M(王懋); Wu, DM(吴东岷); Wang, QB(王强斌)
刊名	NANO RESEARCH
	2015
卷号	8 期号:5 页码:11
关键词	in vivo imaging Ag2S quantum dots second near-infrared window fluorescence drug delivery tumor therapy
通讯作者	Wang, QB (王强斌)
英文摘要	Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform (DOX@PEG-Ag2S) obtained by loading the anti-cancer drug doxorubicin (DOX) into polyethylene glycol-coated silver sulfide quantum dots (PEG-Ag2S QDs) through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability (93 wt.% of DOX to Ag2S QDs), long circulation in blood (t (1/2) = 10.3 h), and high passive tumor-targeting efficiency (8.9% ID/gram) in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose (ID) per gram of tissue. After targeting the tumor tissue, DOX from PEG-Ag2S cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window (NIR-II), the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/3383]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队
推荐引用方式 GB/T 7714	Hu, F,Li, CY,Zhang, YJ,et al. Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform[J]. NANO RESEARCH,2015,8(5):11.
APA	Hu, F,Li, CY,Zhang, YJ,Wang, M,Wu, DM,&Wang, QB.(2015).Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform.NANO RESEARCH,8(5),11.
MLA	Hu, F,et al."Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform".NANO RESEARCH 8.5(2015):11.