Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag-2 S Quantum Dots

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 王强斌团队

	Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag-2 S Quantum Dots
	Wang QB(王强斌)
刊名	ADVANCED FUNCTIONAL MATERIALS
	2014-05
卷号	24 期号:17 页码:2481-2488
关键词	quantum dots near-infrared human mesenchymal stem cells cell tracking in vivo imaging
通讯作者	陈光村
英文摘要	Stem cell therapeutics has emerged as a novel regenerative therapy for tissue repair in the last decade. However, dynamically tracking the transplanted stem cells in vivo remains a grand challenge for stem cell-based regeneration medicine in full understanding the function and the fate of the stem cells. Herein, Ag2S quantum dots (QDs) in the second near-infrared window (NIR-II, 1.0-1.4 m) are employed for dynamically tracking of human mesenchymal stem cells (hMSCs) in vivo with high sensitivity and high spatial and temporal resolution. As few as 1000 Ag2S QDs-labeled hMSCs are detectable in vivo and their fluorescence intensity can maintain up to 30 days. The in situ translocation and dynamic distribution of transplanted hMSCs in the lung and liver can be monitored up to 14 days with a temporal resolution of 100 ms. The in vivo high-resolution imaging indicates the heparin-facilitated translocation of hMSCs from lung to liver as well as the long-term retention of hMSCs in the liver contribute to the treatment of liver failure. The novel NIR-II imaging offers a possibility of tracking stem cells in living animals with both high spatial and temporal resolution, and encourages the future clinical applications in imaging-guided cell therapies.
收录类别	SCI
语种	英语
WOS记录号	WOS:000335658700006
公开日期	2014-12-08
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/1681]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队
推荐引用方式 GB/T 7714	Wang QB. Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag-2 S Quantum Dots[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(17):2481-2488.
APA	Wang QB.(2014).Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag-2 S Quantum Dots.ADVANCED FUNCTIONAL MATERIALS,24(17),2481-2488.
MLA	Wang QB."Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag-2 S Quantum Dots".ADVANCED FUNCTIONAL MATERIALS 24.17(2014):2481-2488.