Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques

	Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques
	Wang B(汪冰); Feng WY(丰伟悦); Chai ZF(柴之芳); Zhao YL(赵宇亮); Wang, B; Feng, WY; Chai, ZF; Zhao, YL
刊名	SCIENCE CHINA-CHEMISTRY
	2015
卷号	58 期号:5 页码:768-779
关键词	nano-bio interface synchrotron-radiation-based analytical techniques interaction
通讯作者	丰伟悦
英文摘要	Understanding the interactions of nanomaterials (NMs) with biomolecules, organelles, cells, and organic tissues at the nano-bio interface can offer important information for their uptake, distribution, translocation, metabolism and degradation in vitro and in vivo, which can help to precisely tune and design "smart" NMs for biomedical applications. However, probing the interactions at the nano-bio interface, which generally requires dedicated analytical methods and tools, is remarkably complicated due to the dynamically changed nature of the nano-bio interface. Because of the advantages of high spatial resolution, high sensitivity, excellent accuracy, low matrix effects and non-destructiveness, synchrotron radiation (SR)-based analytical techniques have become extremely valuable tools. Herein, we present a comprehensive overview of SR-based techniques for the visualized study of NMs at cellular and subcellular interfaces and their transformation in vitro; the exploration of biodistribution, translocation, metabolism and degradation of NMs in vivo; and clarification of the molecular mechanisms of NMs' reactions with biomolecules. Rapid development of advanced light source means that in situ, real-time analysis of NMs at the nano-bio interface will be achieved.
学科主题	Chemistry
类目[WOS]	Chemistry, Multidisciplinary
收录类别	SCI ; EI ; CA
WOS记录号	WOS:000354188900004
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228548]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Wang B,Feng WY,Chai ZF,et al. Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques[J]. SCIENCE CHINA-CHEMISTRY,2015,58(5):768-779.
APA	汪冰.,丰伟悦.,柴之芳.,赵宇亮.,Wang, B.,...&Zhao, YL.(2015).Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques.SCIENCE CHINA-CHEMISTRY,58(5),768-779.
MLA	汪冰,et al."Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques".SCIENCE CHINA-CHEMISTRY 58.5(2015):768-779.