Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size

	Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
	Peng, L; He X(何潇); 张鹏(多); He, X; Zhang, P; Zhang, J; Li, YY; Zhang, JZ; Ma, YH; Ding, YY
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2014
卷号	15 期号:4 页码:6072-6085
关键词	nano-ceria pulmonary toxicity agglomerates size distribution surface chemistry
英文摘要	Ceria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after a single exposure via intratracheal instillation. Two types of nano-ceria with the same distribution of a primary size (3-5 nm), but different redox activity, were used: Ceria-p, synthesized by a precipitation route, and Ceria-h, synthesized by a hydrothermal route. Both Ceria-p and Ceria-h induced oxidative stress, inflammatory responses and cytotoxicity in mice, but their toxicological profiles were quite different. The mean size of Ceria-p agglomerates was much smaller compared to Ceria-h, thereby causing a more potent acute inflammation, due to their higher number concentration of agglomerates and higher deposition rate in the deep lung. Ceria-h had a higher reactivity to catalyzing the generation of reactive oxygen species (ROS), and caused two waves of lung injury: bronchoalveolar lavage (BAL) inflammation and cytotoxicity in the early stage and redox-activity-evoked lipid peroxidation and pro-inflammation in the latter stage. Therefore, the size distribution of ceria-containing agglomerates in the exhaust, as well as their surface chemistry are essential characteristics to assess the potential risks of using nano-ceria as a fuel additive.
学科主题	Chemistry
收录类别	SCI
WOS记录号	WOS:000336841200060
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225047]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Peng, L,He X,Zhang P,et al. Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(4):6072-6085.
APA	Peng, L.,何潇.,张鹏.,He, X.,Zhang, P.,...&张静.(2014).Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,15(4),6072-6085.
MLA	Peng, L,et al."Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15.4(2014):6072-6085.