The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging

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	The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging
	杨文江;Yang, WJ; Zhao, ZQ; Fang, W; Zhang, XZ
刊名	APPLIED RADIATION AND ISOTOPES
	2013
卷号	74 页码:1-5
关键词	DTPA-LSA Tc-99m ASGP Instant lyophilized kit SPECT imaging
英文摘要	Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of Tc-99m-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of Tc-99m-DTPA-LSA. Tc-99m-DTPA-LSA showed high liver uptake in normal mice (> 96% ID/g at 5 min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120 min after injection of the radiotracer. The promising biological properties of Tc-99m-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. (c) 2012 Elsevier Ltd. All rights reserved.
学科主题	Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging
收录类别	SCI
WOS记录号	WOS:000316978400001
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/223754]
专题	高能物理研究所_核技术应用研究中心
推荐引用方式 GB/T 7714	杨文江；Yang, WJ,Zhao, ZQ,Fang, W,et al. The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging[J]. APPLIED RADIATION AND ISOTOPES,2013,74:1-5.
APA	杨文江；Yang, WJ,Zhao, ZQ,Fang, W,&Zhang, XZ.(2013).The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging.APPLIED RADIATION AND ISOTOPES,74,1-5.
MLA	杨文江；Yang, WJ,et al."The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging".APPLIED RADIATION AND ISOTOPES 74(2013):1-5.