99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent

	99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent
	Wang JJ(汪建军); Zhang YH(张延华); Yang WJ(杨文江); Xue JQ(薛井泉); 刘宇(多); Wang, J.; Zhang, Y.; Yang, W.; Xue, J.; Liu, Y.
刊名	JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
	2016
卷号	307 期号:2 页码:1087-1092
通讯作者	汪建军 ; 刘宇（多）
英文摘要	For the purpose to develop novel 99mTc-labeled tumor imaging agents with SPECT, colchicine (CHC) was directly labeled by 99mTc using diethylene triamine pentacetate acid (DTPA) as bifunctional chelating agent. Trimethylcolchicinic acid, derivatived from colchicine, was conjugated to DTPA to get the new ligand DTPA-CHC, which was labeled by 99mTc in the presence of SnCl2 as reducing agent. The radiochem. purity of the 99mTc-DTPA-CHC complex was over 90 %. It had good hydrophilicity and was stable at room temp. The high initial tumor uptake with moderate retention, good tumor/muscle ratios and satisfactory scintigraphic images highlighted the potential of 99mTc-DTPA-CHC for tumor imaging. [on SciFinder(R)]
收录类别	CA
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228868]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang JJ,Zhang YH,Yang WJ,et al. 99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016,307(2):1087-1092.
APA	汪建军.,张延华.,杨文江.,薛井泉.,刘宇.,...&Liu, Y..(2016).99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,307(2),1087-1092.
MLA	汪建军,et al."99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 307.2(2016):1087-1092.