Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China

	Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China
	Li, J; Wang, YF; Kong, DD; Wang, JS; Teng, YG; Li, N; 李娜(多)
刊名	ENVIRONMENTAL MONITORING AND ASSESSMENT
	2015
卷号	187 期号:11 页码:724
关键词	In vitro bioassay Estrogen receptor Androgen receptor Soil sample Endocrine-disrupting chemicals
英文摘要	In the present study, re-combined estrogen receptor (ER) and androgen receptor (AR) gene yeast assays combined with a novel approach based on Monte Carlo simulation were used for evaluation and characterization of soil samples collected from Jilin along the Second Songhua River to assess their antagonist/agonist properties for ER and AR. The results showed that estrogenic activity only occurred in the soil samples collected in the agriculture area, but most soil samples showed anti-estrogenic activities, and the bioassay-derived 4-hydroxytamoxifen equivalents ranged from N.D. to 23.51 mu g/g. Hydrophilic substance fractions were determined as potential contributors associated with anti-estrogenic activity in these soil samples. Moreover, none of the soil samples exhibited AR agonistic potency, whereas 54 % of the soil samples exhibited AR antagonistic potency. The flutamide equivalents varied between N.D. and 178.05 mu g/g. Based on Monte Carlo simulation-related mass balance analysis, the AR antagonistic activities were significantly correlated with the media polar and polar fractions. All of these results support that this novel calculation method can be adopted effectively to quantify and characterize the ER/AR agonists and antagonists of the soil samples, and these data could help provide useful information for future management and remediation efforts.
学科主题	Environmental Sciences & Ecology
类目[WOS]	Environmental Sciences
收录类别	SCI ; EI
WOS记录号	WOS:000363964000066
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228830]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Li, J,Wang, YF,Kong, DD,et al. Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China[J]. ENVIRONMENTAL MONITORING AND ASSESSMENT,2015,187(11):724.
APA	Li, J.,Wang, YF.,Kong, DD.,Wang, JS.,Teng, YG.,...&李娜.(2015).Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China.ENVIRONMENTAL MONITORING AND ASSESSMENT,187(11),724.
MLA	Li, J,et al."Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China".ENVIRONMENTAL MONITORING AND ASSESSMENT 187.11(2015):724.