Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe

	Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe
	Sun, CJ; Yuan, Y; Xu ZH(徐钟河); Li JY(李敬源); Xu, ZH; Ji, TJ; Tian, YH; Wu, S; Lei, JL; Li, JY
刊名	BIOCONJUGATE CHEMISTRY
	2015
卷号	26 期号:2 页码:193-196
通讯作者	李敬源
英文摘要	When stabilized and functionalized by biomolecules, noble metal (such as gold and silver) cluster-based hybrid nanocomposites have shown great promise for biomedical applications, due to their unique physiochemical properties originating from the inorganic elements and specific functionality and biocompatibility from their biological components. Although certain promise for bioimaging, biosensing, and biomimetic catalysis has been demonstrated, it is still a great challenge to integrate the defined functionality of the biomolecules with enhanced or novel physiochemical properties of the metal clusters, under control at the molecular level. Herein, based on molecular dynamics simulation of a gold (Au) cluster assembly, we designed near-infrared (NIR) fluorescent hybrid nanocomposites with multiple Au clusters within an apo H-ferritin (HFt) nanocage. The fluorescence quantum yield of near-infrared (NIR) Au-HFt is about 63.4% and the emission peak is 810 nm. The NIR Au-HFt is one of the first native protein-guided Au cluster-based nanomaterials for in vivo biowindow imaging. In vivo fluorescent imaging and quantification of Au element confirmed that Au-HFt not only retained the kidney targeting properties of HFt well (about 10 times higher Au concentration in kidney than in liver and spleen, the most common organs for nanoparticle accumulation), but also gained strong NIR imaging capability for live animals. The NIR Au-HFt showed powerful tissue penetrating ability, strong fluorescent efficiency, and excellent kidney targeting specificity. These results thus open new opportunities for kidney disease imaging and theranostic applications.
学科主题	Biochemistry & Molecular Biology; Chemistry
类目[WOS]	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
收录类别	SCI
WOS记录号	WOS:000349807200004
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228108]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Sun, CJ,Yuan, Y,Xu ZH,et al. Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe[J]. BIOCONJUGATE CHEMISTRY,2015,26(2):193-196.
APA	Sun, CJ.,Yuan, Y.,徐钟河.,李敬源.,Xu, ZH.,...&Nie, GJ.(2015).Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe.BIOCONJUGATE CHEMISTRY,26(2),193-196.
MLA	Sun, CJ,et al."Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe".BIOCONJUGATE CHEMISTRY 26.2(2015):193-196.