Study on the relationship of reactive oxygen species and biological dose - response curve of selenium

	Study on the relationship of reactive oxygen species and biological dose - response curve of selenium
	Chen, C; Chen, B; Yang, X; Zhou, J; Xu, H
刊名	TRACE ELEMENTS AND ELECTROLYTES
	1997
卷号	14 期号:4 页码:#REF!
关键词	selenium reactive oxygen species Bertrand's rule trace elements biological activity lipid peroxidation glutathione peroxidase
通讯作者	Chen, B (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Anal Tech, POB 27327, Beijing 100800, Peoples R China.
英文摘要	The relationship between dose-biological function of selenium and reactive oxygen species (ROS) was investigated both in vitro and in vivo. The formation of ROS as hydroxyl radical was generated in the reaction mixture of sodium selenite, glutathione (GSH), and hydrogen peroxide proved by electron spin resonance (ESR) and spin trapping technique, and lipid radical was also observed by adding linoleic acid to the reaction mixture, and lipid peroxide was elevated by measuring substances reactive to thiobarbituric acid (TBA). Furthermore, some antioxidants and enzymes as superoxide dismutase (SOD) and catalase (CAT) can decrease this elevation. In addition, the experiment animals were administered a Se-deficient diet and drinking water supplemented with different level of selenite for 21 days, and ig CCl4 (0.7 ml/kg) oil solution 10 ml/kg once. After 24 hours the mice were killed and content of Se, glutathione peroxidase (GSH-Px), lipid peroxidation, and free radical level in liver were detected. There are 4 lines gained which agree with Bertrand's rule. Results show that the concentration of Se and its biological activity is closely related to ROS.
学科主题	Biochemistry & Molecular Biology; Endocrinology & Metabolism
类目[WOS]	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
收录类别	SCI
WOS记录号	WOS:000072228800010
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/226871]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Chen, C,Chen, B,Yang, X,et al. Study on the relationship of reactive oxygen species and biological dose - response curve of selenium[J]. TRACE ELEMENTS AND ELECTROLYTES,1997,14(4):#REF!.
APA	Chen, C,Chen, B,Yang, X,Zhou, J,&Xu, H.(1997).Study on the relationship of reactive oxygen species and biological dose - response curve of selenium.TRACE ELEMENTS AND ELECTROLYTES,14(4),#REF!.
MLA	Chen, C,et al."Study on the relationship of reactive oxygen species and biological dose - response curve of selenium".TRACE ELEMENTS AND ELECTROLYTES 14.4(1997):#REF!.