Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice

	Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice
	Yang, ST; Wang, X; Jia, G; Gu, YQ; Wang, TC; Nie, HY; Ge, CC; Wang, HF; Liu, YF; Ge CC(葛翠翠)
刊名	TOXICOLOGY LETTERS
	2008
卷号	181 期号:3 页码:#REF!
关键词	Carbon nanotubes Intravenous administration Accumulation Toxicity Oxidative stress
通讯作者	Wang, HF (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China.
英文摘要	The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main Organs (such as liver, lung and spleen) in mice were carefully studied. Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice. The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique. Statistically significant changes in organ indices and serum biochemical parameters (LDH, ALT and AST) were observed. The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators (CH 50 level and TNF-alpha level) remained unchanged. No apoptosis was induced in the main organs. The decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWCNTs might be due to the oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
学科主题	Toxicology
类目[WOS]	Toxicology
收录类别	SCI
WOS记录号	WOS:000260646100007
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/226751]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Yang, ST,Wang, X,Jia, G,et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice[J]. TOXICOLOGY LETTERS,2008,181(3):#REF!.
APA	Yang, ST.,Wang, X.,Jia, G.,Gu, YQ.,Wang, TC.,...&葛翠翠.(2008).Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.TOXICOLOGY LETTERS,181(3),#REF!.
MLA	Yang, ST,et al."Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice".TOXICOLOGY LETTERS 181.3(2008):#REF!.