Visual attention deficits in Alzheimer's disease: an fMRI study

	Visual attention deficits in Alzheimer's disease: an fMRI study
	Hao, J; Li, KC; Li, K; Zhang, DX; Wang, W; Yang, YH; Yan, B; Shan, BC; Zhou, XL; Li K(李可)
刊名	NEUROSCIENCE LETTERS
	2005
卷号	385 期号:1 页码:#REF!
关键词	functional MRI visual search attention Alzheimer's disease
通讯作者	Li, KC (reprint author), Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, 45 Changchun St, Beijing 100053, Peoples R China.
英文摘要	Cognitive and neuroscience studies indicate that attentional operations are impaired in Alzheimer's disease (AD). Our goal was to define the anatomical areas of activation associated with visual attention processing and to define deficits or changes that may occur in AD patients compared with control group. Thirteen AD patients and 13 age- and education-matched normal controls were tested in two visual search tasks (one was a conjunction task, where feature binding is required. The other was a subset task, where group stimuli is needed without feature binding) using fMRI techniques. After stereotactical normalization, voxel-by-voxel t statistics was used to compare activated brain areas between patients and control subjects. Our findings suggest that both search tasks are controlled by partially overlapping cerebral networks, including parietal, frontal and occipital-temporal cortical regions and primary visual cortex. The AD patient group showed less activation in both parietal lobes and the left frontal regions, while increased activation was found in the right frontal lobes and the right occipito-temporal cortical regions with the conjunction task. In the subset task, decreased activation in AD patients was seen in the left parietal lobe and bilateral frontal lobes, while increased activation was seen in both medial temporal lobes. In addition, for the comparison between tasks, The difference is very small for AD patients. Control group showed a higher amplitude in the fight prefrontal region, temporal cortical regions and parietal lobe. These results indicate that attention deficits in AD patients may be attributed to both binding problem and grouping inefficiency. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
收录类别	SCI
WOS记录号	WOS:000230745800004
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225528]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Hao, J,Li, KC,Li, K,et al. Visual attention deficits in Alzheimer's disease: an fMRI study[J]. NEUROSCIENCE LETTERS,2005,385(1):#REF!.
APA	Hao, J.,Li, KC.,Li, K.,Zhang, DX.,Wang, W.,...&单保慈.(2005).Visual attention deficits in Alzheimer's disease: an fMRI study.NEUROSCIENCE LETTERS,385(1),#REF!.
MLA	Hao, J,et al."Visual attention deficits in Alzheimer's disease: an fMRI study".NEUROSCIENCE LETTERS 385.1(2005):#REF!.