Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging

	Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging
	Zhou LJ(周亮君); Gu ZJ(谷战军); Liu XX(刘潇潇); Zhou, LJ; Gu, ZJ; Liu, XX; Yin, WY; Tian, G; Yan, L; Jin, S
刊名	JOURNAL OF MATERIALS CHEMISTRY
	2012
卷号	22 期号:3 页码:966-974
英文摘要	Lanthanide (Ln(3+)) doped Gd2O3 nanoparticles (NPs) have been prepared via a thermal treatment of gadolinium carbonate precursor, which was obtained by simple hydrothermal treatment of Gd(NO3)(3) solution in the presence of urea and glycerol. The size of the nanoparticles could be fine tuned from 270 to 10 nm by varying the amount of glycerol, which acted as a chelating agent to control the size of the nanoparticles. Calcination of the gadolinium carbonate nanoparticles at 500 degrees C led to the formation of uniform Gd2O3 nanoparticles without any obvious morphology change. By doping the lanthanide ions (Yb, Er/Tm) into the Gd2O3 host matrix, these nanoparticles emitted strong upconversion (UC) fluorescence under 980 nm near infrared (NIR) excitation. Moreover, their emission colors could be tuned by simply changing either the co-dopant concentration or the dopant species. Water dispersibility was achieved by forming a silica layer on the surface of the Gd2O3 nanoparticles. The possibility of using these silica-coated upconversion nanoparticles for optical imaging in vitro/in vivo has been demonstrated. It was also shown that these Gd2O3 nanoparticles brightened the T-1-weighted images and enhanced r(1) relaxivity of water protons, which suggested they act as T-1 contrast agents for magnetic resonance (MR) imaging. Thus, Gd2O3 nanoparticles doped with Ln(3+) ions provide the dual modality of optical and magnetic resonance imaging.
学科主题	Chemistry; Materials Science
收录类别	SCI
WOS记录号	WOS:000299212700027
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224086]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zhou LJ,Gu ZJ,Liu XX,et al. Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(3):966-974.
APA	周亮君.,谷战军.,刘潇潇.,Zhou, LJ.,Gu, ZJ.,...&赵宇亮.(2012).Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging.JOURNAL OF MATERIALS CHEMISTRY,22(3),966-974.
MLA	周亮君,et al."Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging".JOURNAL OF MATERIALS CHEMISTRY 22.3(2012):966-974.