Single-layer tungsten oxide as intelligent photo-responsive nanoagents for permanent male sterilization

	Single-layer tungsten oxide as intelligent photo-responsive nanoagents for permanent male sterilization
	Liu,Zhen; Liu,Xianjun; Ran,Xiang; Ju,Enguo; Ren,Jinsong; Qu,Xiaogang
刊名	biomaterials
	2015
卷号	69 期号:17 页码:56-64
关键词	PEGYLATED W18O49 NANOWIRES UP-CONVERSION NANOPROBES GERM-CELL APOPTOSIS IN-VIVO CONTRAST AGENTS MAGNETIC NANOPARTICLES PHOTODYNAMIC THERAPY CANCER DOGS DRUG
通讯作者	ren,js
英文摘要	permanent male sterilization has been recognized as useful tools for the development of neuter experimental animals and fattening livestock, as well as efficient control of pet overpopulation. traditional routes such as surgical ways, chemical injections, and anti-fertility vaccines have addressed these crucial problems with idea outcomes. however, these routes usually bring out serious pain and infection towards animals, as well as induce long-term adverse reaction and immune suppression. thus, a convenient, but non-surgical strategy for male sterilization under a mild manner is highly desirable. here, for the first time, we demonstrate a novel platform for male sterilization by using single-layer wo2.72 nanosheets as smart photo-responsive sterilants. upon a 980 nm irradiation, these nanoagents can possess intrinsic nir-induced hyperthermia and sensitize the formation of singlet oxygen due to the cooperation of photothermal and photodynamic effects. mechanism of cellular injury can be attributed to the denaturation of protein and apoptosis-related death. moreover, long-term toxicity and possible metabolism route after testicular injection are discussed, indicating the neglectable systemic toxicity and high bio-compatibility of our nanoagents. overall, our strategy can extremely overcome the shortcomings in various routine routes and suggest the new biological application of nanomaterials. (c) 2015 elsevier ltd. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000361409500007
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64592]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu,Zhen,Liu,Xianjun,Ran,Xiang,et al. Single-layer tungsten oxide as intelligent photo-responsive nanoagents for permanent male sterilization[J]. biomaterials,2015,69(17):56-64.
APA	Liu,Zhen,Liu,Xianjun,Ran,Xiang,Ju,Enguo,Ren,Jinsong,&Qu,Xiaogang.(2015).Single-layer tungsten oxide as intelligent photo-responsive nanoagents for permanent male sterilization.biomaterials,69(17),56-64.
MLA	Liu,Zhen,et al."Single-layer tungsten oxide as intelligent photo-responsive nanoagents for permanent male sterilization".biomaterials 69.17(2015):56-64.