Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis

	Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis
	Chen,Zhaowei; Liu,Zhen; Li,Zhenhua; Ju,Enguo; Gao,Nan; Zhou,Li; Ren,Jinsong; Qu,Xiaogang
刊名	biomaterials
	2015
卷号	39 期号:1 页码:15-22
关键词	NEAR-INFRARED-LIGHT COLLAGEN-INDUCED ARTHRITIS RESONANCE ENERGY-TRANSFER ACID HYBRIDIZATION ASSAY CORE-SHELL NANOPARTICLES PHOTODYNAMIC THERAPY HYALURONIC-ACID UPCONVERTING NANOPARTICLES QUANTUM DOTS DEGRADATION
通讯作者	ren,js
英文摘要	over-generation of reactive oxygen species (ros) is closely associated with the biological processes of rheumatoid arthritis (ra). thus, efficient monitoring ros in inflammatory joints would be essential for better understanding the pathogenesis and optimizing therapeutic interventions. herein, we designed a ratiometric nanoprobe utilizing upconversion nanoparticles (ucnps) conjugated with chromophore labeled hyaluronic acid (ha) for high sensitively sensing ros in the aqueous solution, bioimaging ros in inflammatory mimic cells and diagnosing ra in vivo. in this approach, the conjugation of ha conferred ucnps not only water solubility but also biocompatibility and ros recognizing properties. particularly, the ha backbone cleavage and detachment of chromophore labeled ha fragments from ucnps induced by ros inhibited the luminescent energy transfer (lret) and allowed rational metric upconversion luminescence (ucl) emission as the detection signal. importantly, the upconversion nanoprobe showed high effectiveness for early assessing the treatment response of arthritic animals to an antiarthritic drug-methotrexate (mtx). (c) 2014 elsevier ltd. all rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64584]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen,Zhaowei,Liu,Zhen,Li,Zhenhua,et al. Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis[J]. biomaterials,2015,39(1):15-22.
APA	Chen,Zhaowei.,Liu,Zhen.,Li,Zhenhua.,Ju,Enguo.,Gao,Nan.,...&Qu,Xiaogang.(2015).Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis.biomaterials,39(1),15-22.
MLA	Chen,Zhaowei,et al."Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis".biomaterials 39.1(2015):15-22.