Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel

	Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel
	Li,Wen; Wang,Jiasi; Ren,Jinsong; Qu,Xiaogang
刊名	chemical science
	2015
卷号	6 期号:12 页码:6762-6768
关键词	NANOSTRUCTURED SURFACES EXTRACELLULAR-MATRIX SMALL MOLECULES LIVING CELLS CANCER-CELLS STEM-CELLS RELEASE ATTACHMENT PLATELETS GROWTH
通讯作者	qu,xg
英文摘要	design of biological signal-responsive biomaterials is essential for controlling cell-cell and cell-matrix interactions. herein, we developed a dynamic hydrogel to control cell adhesion with biological signals in a cellular microenvironment. the basic principle was based on using nucleic acid aptamer to recognize cell signalling and control the display of bioligands on the hydrogel. not only exogenous signalling but also endogenous signalling secreted by surrounding cells could activate the dynamic scaffold and tune the cell adhesion state. since diverse aptamers have been developed, our design can be extended to multiple biological inputs. the biochemical signal-responsive system will greatly enhance the understanding of complex biological processes as well as the ability to manipulate cellular behaviors.
收录类别	SCI
语种	英语
WOS记录号	WOS:000365225300008
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64583]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li,Wen,Wang,Jiasi,Ren,Jinsong,et al. Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel[J]. chemical science,2015,6(12):6762-6768.
APA	Li,Wen,Wang,Jiasi,Ren,Jinsong,&Qu,Xiaogang.(2015).Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel.chemical science,6(12),6762-6768.
MLA	Li,Wen,et al."Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel".chemical science 6.12(2015):6762-6768.