ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH

	ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH
	Wang,Yinghui; Song,Shuyan; Liu,Jianhua; Liu,Dapeng; Zhang,Hongjie
刊名	angewandte chemie-international edition
	2015
卷号	54 期号:2 页码:536-540
关键词	UP-CONVERSION NANOPARTICLES LANTHANIDE-DOPED NANOPARTICLES CORE-SHELL NANOPARTICLES IN-VITRO PHOTODYNAMIC THERAPY MESOPOROUS SILICA QUANTUM DOTS GOLD NANOPARTICLES CONTRAST AGENT CANCER-THERAPY
通讯作者	liu,dp
英文摘要	limited therapeutic efficiency and severe side effects in patients are two major issues existing in current chemotherapy of cancers in clinic. to design a proper theranostic platform seems thus quite needed to target cancer cells accurately by bioimaging and simultaneously release drugs on demand without premature leakage. a novel zno-functionalized upconverting nanotheranostic platform has been fabricated for clear multi-modality bioimaging (upconversion luminescence (ucl), computed tomography (ct), and magnetic resonance imaging (mri)) and specific ph-triggered on-demand drug release. in our theranostic platform multi-modality imaging provides much more detailed and exact information for cancer diagnosis than single-modality imaging. in addition, zno can play the role of a gatekeeper to efficiently block the drug in the mesopores of the as-prepared agents until it is dissolved in the acidic environment around tumors to realize sustained release of the drug. more importantly, the biodegradable zno, which is non-toxic against normal tissues, endows the as-prepared agents with high therapeutic effectiveness but very low side effects. these findings are of great interests and will inspire us much to develop novel effective imaging-guided on-demand chemotherapies in cancer treatment.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64549]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang,Yinghui,Song,Shuyan,Liu,Jianhua,et al. ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH[J]. angewandte chemie-international edition,2015,54(2):536-540.
APA	Wang,Yinghui,Song,Shuyan,Liu,Jianhua,Liu,Dapeng,&Zhang,Hongjie.(2015).ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH.angewandte chemie-international edition,54(2),536-540.
MLA	Wang,Yinghui,et al."ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH".angewandte chemie-international edition 54.2(2015):536-540.