Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation

	Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation
	Du,Zhi-Jun; Guan,Jing; Wu,Guo-Jie; Xu,Peng; Gao,Lian-Xun; Han,Fu-She
刊名	journal of the american chemical society
	2015
卷号	137 期号:2 页码:632-635
关键词	MIYAURA COUPLING REACTIONS ASYMMETRIC-SYNTHESIS STEREOSELECTIVE-SYNTHESIS PHOSPHORUS LIGANDS CHIRAL LIGANDS ACTIVATION CATALYSIS OXIDES HYDROGENATION ACID
通讯作者	han,fs
英文摘要	we present the enantioselective synthesis of p-stereogenic phosphinamides through pd-catalyzed desymmetric ortho c-h arylation of diarylphosphinamides with boronic esters. the method represents the first example of the synthesis of p-stereogenic phosphorus compounds via the desymmetric c-h functionalization strategy. the reaction proceeded efficiently with a wide array of reaction partners to afford the p-stereogenic phosphinamides in up to 74% yield and 98% ee. the efficiency was further demonstrated by gram scale syntheses. moreover, the flexible conversion of the p-stereogenic phosphinamides into various types of p-stereogenic phosphorus derivatives was also elaborated. thus, the protocol provides a novel tool for the efficient and versatile synthesis of p-stereogenic compounds.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64528]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Du,Zhi-Jun,Guan,Jing,Wu,Guo-Jie,et al. Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation[J]. journal of the american chemical society,2015,137(2):632-635.
APA	Du,Zhi-Jun,Guan,Jing,Wu,Guo-Jie,Xu,Peng,Gao,Lian-Xun,&Han,Fu-She.(2015).Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation.journal of the american chemical society,137(2),632-635.
MLA	Du,Zhi-Jun,et al."Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation".journal of the american chemical society 137.2(2015):632-635.