An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)
	Ji, CL; Li, F; Wang, Q; Zhao, JM; Sun, ZD ; Wu, HF
刊名	CHEMOSPHERE
	2016-02-01
卷号	144 页码:527-539
关键词	Gender-specific Mytilus galloprovincialis Proteomics Metabolomics Tetrabromobisphenol A
ISSN号	0045-6535
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
产权排序	[Ji, Chenglong; Li, Fei; Wang, Qing; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China; [Sun, Zuodeng] Shandong Hydrobios Resources Conservat & Manageme, Yantai 264003, Shandong, Peoples R China
英文摘要	Tetrabromobisphenol A (TBBPA), accounting for the largest production of brominated flame-retardants (BFRs) along the Laizhou Bay in China, is of great concern due to its diverse toxicities. In this study, we focused on the gender-specific responses of TBBPA in mussel Mytilus galloprovincialis using an integrated proteomic and metabolomic approach. After exposure of TBBPA (10 mu g L-1) for one month, a total of 9 metabolites and 67 proteins were altered in mussel gills from exposed group. The significant changes of metabolites in female mussel gills from exposed group exhibited the disturbances in energy metabolism and osmotic regulation, while in male samples only be found the variation of metabolites related to osmotic regulation. iTRAQ-based proteomic analysis showed biological differences between male and female mussel gills from solvent control group. The higher levels of proteins related to primary and energy metabolism and defense mechanisms in male mussel gills meant a greater anti-stress capability of male mussels. Further analysis revealed that TBBPA exposure affected multiple biological processes consisting of production and development, material and energy metabolism, signal transduction, gene expression, defense mechanisms and apoptosis in both male and female mussels with different mechanisms. Specially, the responsive proteins of TBBPA in male mussels signified higher tolerance limits than those in female individuals, which was consistent with the biological differences between male and female mussel gills from solvent control group. This work suggested that the gender differences should be considered in ecotoxicology. (C) 2015 Elsevier Ltd. All rights reserved.
研究领域[WOS]	Environmental Sciences & Ecology
关键词[WOS]	BROMINATED FLAME RETARDANTS ; NMR-BASED METABOLOMICS ; 2,2',4,4'-TETRABROMODIPHENYL ETHER ; MOLECULAR CHARACTERIZATION ; IN-VITRO ; PROTEINS ; GILL ; EXPRESSION ; BIOMARKERS ; APOPTOSIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000367774400069
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/9303]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室海岸带生物资源高效利用研究与发展中心
作者单位	1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS 2.Shandong Hydrobios Resources Conservat & Manageme
推荐引用方式 GB/T 7714	Ji, CL,Li, F,Wang, Q,et al. An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)[J]. CHEMOSPHERE,2016,144:527-539.
APA	Ji, CL,Li, F,Wang, Q,Zhao, JM,Sun, ZD,&Wu, HF.(2016).An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA).CHEMOSPHERE,144,527-539.
MLA	Ji, CL,et al."An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)".CHEMOSPHERE 144(2016):527-539.