Effect of Urea on Phase Transition of Poly(N-isopropylacrylamide) and Poly(N,N-diethylacrylamide) Hydrogels: A Clue for Urea-Induced Denaturation

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	Effect of Urea on Phase Transition of Poly(N-isopropylacrylamide) and Poly(N,N-diethylacrylamide) Hydrogels: A Clue for Urea-Induced Denaturation
	Wang, Jian 1,2; Liu, Biaolan 1,2; Ru, Geying 1; Bai, Jia 1,2; Feng, Jiwen 1
刊名	MACROMOLECULES
	2016-01-12
卷号	49 期号:1 页码:234-243
英文摘要	H-1 MAS NMR spectroscopy has been applied to study the urea effect on phase transition of two similar thermosensitive polymer hydrogels: poly(N-isopropylacrylamide) (PNIPAM) and poly(N,N-diethylacrylamide) (PDEA). It is found that urea influences the phase transition of the hydrogels in opposite ways: lowering the lower critical solution temperature (LCST) of PNIPAM and hence stabilizing its globular structure, whereas raising the LCST of PDEA and destabilizing the globular structure. The self-diffusion coefficient and urea-polymer nuclear Overhauser effect (NOE) measurement reveal that urea has a stronger interaction with PNIPAM than with PDEA. Moreover, the enhanced positive water-PNIPAM NOE suggests that urea not only interacts directly with PNIPAM via hydrogen bond but also intensifies the hydrogen bonding interaction between water and PNIPAM. We suggest that different urea-polymer hydrogen bonding interaction due to the presence or absence of amide hydrogen is correlated with the distinct LCST variation of PNIPAM and PDEA.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Polymer Science
研究领域[WOS]	Polymer Science
关键词[WOS]	N-ISOPROPYLACRYLAMIDE HYDROGELS ; PROTEIN DENATURATION ; NMR-SPECTROSCOPY ; AQUEOUS-SOLUTION ; THERMORESPONSIVE POLYMERS ; HYDROPHOBIC INTERACTIONS ; PREFERENTIAL ADSORPTION ; H-1-NMR SPECTROSCOPY ; COPOLYMER MICROGELS ; TISSUE SAMPLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000368322000027
公开日期	2016-03-22
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9155]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jian,Liu, Biaolan,Ru, Geying,et al. Effect of Urea on Phase Transition of Poly(N-isopropylacrylamide) and Poly(N,N-diethylacrylamide) Hydrogels: A Clue for Urea-Induced Denaturation[J]. MACROMOLECULES,2016,49(1):234-243.
APA	Wang, Jian,Liu, Biaolan,Ru, Geying,Bai, Jia,&Feng, Jiwen.(2016).Effect of Urea on Phase Transition of Poly(N-isopropylacrylamide) and Poly(N,N-diethylacrylamide) Hydrogels: A Clue for Urea-Induced Denaturation.MACROMOLECULES,49(1),234-243.
MLA	Wang, Jian,et al."Effect of Urea on Phase Transition of Poly(N-isopropylacrylamide) and Poly(N,N-diethylacrylamide) Hydrogels: A Clue for Urea-Induced Denaturation".MACROMOLECULES 49.1(2016):234-243.