Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells
	Yin, Nuoya; Yao, Xinglei; Qin, Zhanfen; Wang, Yuan-Liang; Faiola, Francesco
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
	2015-10-01
卷号	36 期号:1 页码:181-187
关键词	Bisphenol A (BPA) Stem cell toxicology Neurotoxicity Embryonic stem cells (ESCs) Developmental toxicity Neural ectoderm
英文摘要	The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell (ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A (BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effectsofBPApreviouslydetectedby in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
研究领域[WOS]	Environmental Sciences
WOS记录号	WOS:000362983500022
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32521]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Yin, Nuoya,Yao, Xinglei,Qin, Zhanfen,et al. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2015,36(1):181-187.
APA	Yin, Nuoya,Yao, Xinglei,Qin, Zhanfen,Wang, Yuan-Liang,&Faiola, Francesco.(2015).Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,36(1),181-187.
MLA	Yin, Nuoya,et al."Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 36.1(2015):181-187.