The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity

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	The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity
	Chen, Xiufang 2,7; Wang, Yue 3; Feng, Tianquan 4; Yi, Ming 5,6; Zhang, Xingan 2; Zhou, Da 1
刊名	JOURNAL OF THEORETICAL BIOLOGY
	2016-02-07
卷号	390 页码:40-49
关键词	Cancer stem cell model Multi-phenotypic model Transient dynamics Cell plasticity
英文摘要	The paradigm of phenotypic plasticity indicates reversible relations of different cancer cell phenotypes, which extends the cellular hierarchy proposed by the classical cancer stem cell (CSC) theory. Since it is still questionable if the phenotypic plasticity is a crucial improvement to the hierarchical model or just a minor extension to it it is worthwhile to explore the dynamic behavior characterizing the reversible phenotypic plasticity. In this study we compare the hierarchical model and the reversible model in predicting the cell-state dynamics observed in biological experiments. Our results show that the hierarchical model shows significant disadvantages over the reversible model in describing both long-term stability (phenotypic equilibrium) and short-term transient dynamics (overshoot) in cancer cell populations. In a very specific case in which the total growth of population due to each cell type is identical, the hierarchical model predicts neither phenotypic equilibrium nor overshoot, whereas the reversible model succeeds in predicting both of them. Even though the performance of the hierarchical model can be improved by relaxing the specific assumption, its prediction to the phenotypic equilibrium strongly depends on a precondition that may be unrealistic in biological experiments. Moreover, it still does not show as rich dynamics as the reversible model in capturing the overshoots of both CSCs and non-CSCs. By comparison, it is more likely for the reversible model to correctly predict the stability of the phenotypic mixture and various types of overshoot behavior. (C) 2015 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biology ; Mathematical & Computational Biology
研究领域[WOS]	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
关键词[WOS]	STEM-CELLS ; TUMOR-GROWTH ; POPULATIONS ; MODEL ; HETEROGENEITY ; DIVISION ; NOISE ; STATE ; KEY
收录类别	SCI
语种	英语
WOS记录号	WOS:000367770400004
公开日期	2016-03-08
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9139]
专题	武汉物理与数学研究所_数学物理与应用研究部
作者单位	1.Xiamen Univ, Sch Math Sci, Xiamen 361005, Peoples R China 2.Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China 3.Univ Washington, Dept Appl Math, Seattle, WA 98195 USA 4.Nanjing Normal Univ, Sch Teachers Educ, Nanjing 210023, Jiangsu, Peoples R China 5.Huazhong Agr Univ, Dept Phys, Coll Sci, Wuhan 430070, Hubei, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 7.Qilu Inst Technol, Sch Comp Sci & Informat Engn, Jinan 250000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xiufang,Wang, Yue,Feng, Tianquan,et al. The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity[J]. JOURNAL OF THEORETICAL BIOLOGY,2016,390:40-49.
APA	Chen, Xiufang,Wang, Yue,Feng, Tianquan,Yi, Ming,Zhang, Xingan,&Zhou, Da.(2016).The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity.JOURNAL OF THEORETICAL BIOLOGY,390,40-49.
MLA	Chen, Xiufang,et al."The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity".JOURNAL OF THEORETICAL BIOLOGY 390(2016):40-49.