Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin
	Ma, XL; Zhang, FX; Dong, F; Bao, L; Zhang, X
刊名	MOLECULAR PAIN
	2015
卷号	11 期号:1 页码:22-22
关键词	DORSAL-ROOT GANGLION PERIPHERAL NEUROPATHIC PAIN PRIMARY AFFERENT NEURONS EPIDERMAL NERVE-FIBERS GATED SODIUM CURRENTS TOPICAL CAPSAICIN VANILLOID RECEPTOR 8-PERCENT PATCH SENSORY NEURONS INFLAMMATORY PAIN
通讯作者	Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn
英文摘要	The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches. The present study provided evidence showing that the single application of capsaicin dose-dependently alleviated nociceptive hypersensitivity, and reduced the action potential firing in small-diameter neurons of the dorsal root ganglia (DRG) in rats and mice. Pre-treatment with capsaicin reduced formalin-induced acute nocifensive behavior after a brief hyperalgesia in rats and mice. The inhibitory effects of capsaicin were calcium-dependent, and mediated by the capsaicin receptor (transient receptor potential vanilloid type-1). We further found that capsaicin exerted inhibitory effects on the persistent nociceptive hypersensitivity induced by peripheral inflammation and nerve injury. Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.
学科主题	Neurosciences
WOS标题词	Neurosciences & Neurology
收录类别	SCI
语种	英语
WOS记录号	WOS:000353947400001
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3950]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Ma, XL,Zhang, FX,Dong, F,et al. Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin[J]. MOLECULAR PAIN,2015,11(1):22-22.
APA	Ma, XL,Zhang, FX,Dong, F,Bao, L,&Zhang, X.(2015).Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.MOLECULAR PAIN,11(1),22-22.
MLA	Ma, XL,et al."Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin".MOLECULAR PAIN 11.1(2015):22-22.