A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4

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	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4
	Bian, WJ; Miao, WY; He, SJ; Wan, ZF; Luo, ZG; Yu, X
刊名	DEVELOPMENTAL NEUROBIOLOGY
	2015
卷号	75 期号:8 页码:805-822
关键词	PROTEIN-KINASE-C BETA-CATENIN MOLECULAR-MECHANISMS HIPPOCAMPAL-NEURONS WNT RECEPTOR GROWTH SYNAPTOGENESIS TRANSCRIPTION ARBORIZATION
通讯作者	Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,yuxiang@ion.ac.cn
英文摘要	The morphology of the dendritic tree is critical to neuronal function and neural circuit wiring. Several Wnt family members have been demonstrated to play important roles in dendrite development. However, the Wnt receptors responsible for mediating this process remain largely elusive. Using primary hippocampal neuronal cultures as a model system, we report that Frizzled4 (Fzd4), a member of the Fzd family of Wnt receptors, specifically signals downstream of Wnt5a to promote dendrite branching and growth. Interestingly, the less conserved distal PDZ binding motif of Fzd4, and not its conserved proximal Dvl-interacting PDZ motif, is required for mediating this effect. We further showed that Dvl signaled parallel to and independent of Fzd4 in promoting dendrite growth. Unlike most previously described pathways, Wnt5a/Fzd4 signaling promoted dendrite development in an activity-independent and autocrine fashion. Together, these results provide the first identification of a Wnt receptor for regulating dendrite development in the mammalian system, and demonstrate a novel function of the distal PDZ motif of Fzd4 in dendrite morphogenesis, thereby expanding our knowledge of the complex roles of Wnt signaling in neural development. (c) 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 805?822, 2015
学科主题	Developmental Biology; Neurosciences
WOS标题词	Developmental Biology ; Neurosciences & Neurology
收录类别	SCI
语种	英语
WOS记录号	WOS:000358125800002
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3940]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Bian, WJ,Miao, WY,He, SJ,et al. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4[J]. DEVELOPMENTAL NEUROBIOLOGY,2015,75(8):805-822.
APA	Bian, WJ,Miao, WY,He, SJ,Wan, ZF,Luo, ZG,&Yu, X.(2015).A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.DEVELOPMENTAL NEUROBIOLOGY,75(8),805-822.
MLA	Bian, WJ,et al."A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4".DEVELOPMENTAL NEUROBIOLOGY 75.8(2015):805-822.