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	Optimizing the integrated pulsed amperometric multicycle step waveform for the determination of tetracyclines
	Cai, YE; Cai, YQ; Shi, YL; Mou, S; Lu, YQ
	2006
会议名称	18th International Ion Chromatography Symposium
会议日期	SEP 18-21, 2005
会议地点	Montreal, CANADA
关键词	integrated pulsed amperometric detection multi-IPAD tetracyclines high-performance liquid chromatography
英文摘要	A method of modified integrated pulsed amperometric detection with multicycle step waveform (Multi-IPAD) following high-performance liquid chromatography (HPLC) was applied for the determination of tetracyclines (TCs) including dimethyltetracycline (DMTC), oxytetracycline (OTC) and tetracycline (TC). The key advantages of the Multi-IPAD are the abilities to enhance sensitivity and reproducibility and the ability to keep working electrode clean through the use of a high-frequent waveform alteration in integration step and the use of a cleaning potential, which is quite different from conventional three-step potential waveform. The analyses were carried out using the mobile phase of acetonitrile-water mixture solution (10:90, v/v) containing 1% perchloric acid on a C-18 column at a flow rate of 0.21 mL/min. The IPAD waveform parameters were optimized to maximize the signal-to-noise ratio (S/N) and successfully applied for the sensitive detection of TCs. The detection limits (S/N = 3, 20 mu L injected) were 0.07 mg/L for DMTC, 0.08 mg/L for OTC and 0.05 mg/L for TC. The peak height relative standard deviations (RSDs) of every compound for replicate injection (n = 15) determined were below 4.6%. (c) 2005 Elsevier B.V. All rights reserved.
ISSN号	0021-9673
内容类型	会议论文
源URL	[http://ir.rcees.ac.cn/handle/311016/24742]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Cai, YE,Cai, YQ,Shi, YL,et al. Optimizing the integrated pulsed amperometric multicycle step waveform for the determination of tetracyclines[C]. 见:18th International Ion Chromatography Symposium. Montreal, CANADA. SEP 18-21, 2005.

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