Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb
	Ogunlana, Olubanke Olujoke 1; He, Wen Jun 2; Fan, Jun Ting 2; Zeng, Guang Zhi 2; Ji, Chang Jiu 2; Zheng, Yu Quing 2; Olagunju, Joseph Abayomi 3; Akindahunsi, Afolabi Akintunde 4; Tan, Ning Hua 2
刊名	PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2015-11-01
卷号	28 期号:6 页码:2191-2198
关键词	Caesalpinia bonduc flavonoids cytotoxic activity
英文摘要	The extraction, fractionation and recognition of flavonoids from the ethanolic extract of young twigs and leaves of C. bonduc were carried out. In addition, cytotoxic study of the flavonoids on two cancer cell lines, BGC-823 and HeLa was carried our using sulphorhodamine B assay. Seven flavonoids, six of which are being reported for the first time in this plant, were isolated. Their structures were identified by MS and NMR spectroscopic methods. Petroleum ether, ethyl acetate and water fractions exhibited moderate cytotoxic activity against HeLa cells. Five compounds showed cytotoxic activity against HeLa cell in comparison with Paclitaxel, while only one compound showed a good degree of cytotoxic activity against BGC-823 cell in comparison to Paclitaxel. The results obtained showed a structure activity relationship.
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	ANTIPROLIFERATIVE ACTIVITY ; APOPTOSIS ; CELLS ; HOMOISOFLAVONOIDS ; FURANODITERPENES ; CONSTITUENTS ; DITERPENES ; QUERCETIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000366881700040
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25329]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Lagos State Univ, Dept Med Biochem, Coll Med, Fac Basic Med Sci, Ikeja, Lagos State, Nigeria 4.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria
推荐引用方式 GB/T 7714	Ogunlana, Olubanke Olujoke,He, Wen Jun,Fan, Jun Ting,et al. Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb[J]. PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,2015,28(6):2191-2198.
APA	Ogunlana, Olubanke Olujoke.,He, Wen Jun.,Fan, Jun Ting.,Zeng, Guang Zhi.,Ji, Chang Jiu.,...&Tan, Ning Hua.(2015).Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb.PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,28(6),2191-2198.
MLA	Ogunlana, Olubanke Olujoke,et al."Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb".PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 28.6(2015):2191-2198.