Mechano-biological Coupling of Cellular Responses to Microgravity

	Mechano-biological Coupling of Cellular Responses to Microgravity
	Long M(龙勉); Wang YR(王育人); Zheng HQ; Shang P; Duan EK; Lu DY
刊名	MICROGRAVITY SCIENCE AND TECHNOLOGY
	2015-09
通讯作者邮箱	mlong@imech.ac.cn
卷号	27 期号:6 页码:505-514
关键词	Microgravity Mechanobiology Mechanotransduction Cells
ISSN号	0938-0108
通讯作者	Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.
产权排序	[Long, Mian; Wang, Yuren; Lu, Dongyuan] Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China; [Long, Mian; Lu, Dongyuan] Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China; [Long, Mian; Lu, Dongyuan] Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; [Zheng, Huiqiong] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Lab Photosynth & Environm Biol, Beijing 100190, Peoples R China; [Shang, Peng] Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Peoples R China; [Duan, Enkui] Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing 100190, Peoples R China
中文摘要	Cellular response to microgravity is a basic issue in space biological sciences as well as space physiology and medicine. It is crucial to elucidate the mechano-biological coupling mechanisms of various biological organisms, since, from the principle of adaptability, all species evolved on the earth must possess the structure and function that adapts their living environment. As a basic element of an organism, a cell usually undergoes mechanical and chemical remodeling to sense, transmit, transduce, and respond to the alteration of gravitational signals. In the past decades, new computational platforms and experimental methods/techniques/devices are developed to mimic the biological effects of microgravity environment from the viewpoint of biomechanical approaches. Mechanobiology of plant gravisensing in the responses of statolith movements along the gravity vector and the relevant signal transduction and molecular regulatory mechanisms are investigated at gene, transcription, and protein levels. Mechanotransduction of bone or immune cell responses and stem cell development and tissue histogenesis are elucidated under microgravity. In this review, several important issues are briefly discussed. Future issues on gravisensing and mechanotransducing mechanisms are also proposed for ground-based studies as well as space missions.
分类号	二类/Q2
类目[WOS]	Engineering, Aerospace ; Thermodynamics ; Mechanics
研究领域[WOS]	Engineering ; Thermodynamics ; Mechanics
关键词[WOS]	EMBRYONIC STEM-CELLS ; ARABIDOPSIS-THALIANA ; SIMULATED MICROGRAVITY ; AMYLOPLAST DISPLACEMENT ; MAGNETIC-FIELD ; IN-VITRO ; GRAVITROPISM ; DIFFERENTIATION ; GRAVITY ; STRESS
收录类别	SCI ; EI
原文出处	http://dx.doi.org/10.1007/s12217-015-9464-7
语种	英语
WOS记录号	WOS:000366103800012
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/58368]
专题	力学研究所_国家微重力实验室
推荐引用方式 GB/T 7714	Long M,Wang YR,Zheng HQ,et al. Mechano-biological Coupling of Cellular Responses to Microgravity[J]. MICROGRAVITY SCIENCE AND TECHNOLOGY,2015,27(6):505-514.
APA	龙勉,王育人,Zheng HQ,Shang P,Duan EK,&Lu DY.(2015).Mechano-biological Coupling of Cellular Responses to Microgravity.MICROGRAVITY SCIENCE AND TECHNOLOGY,27(6),505-514.
MLA	龙勉,et al."Mechano-biological Coupling of Cellular Responses to Microgravity".MICROGRAVITY SCIENCE AND TECHNOLOGY 27.6(2015):505-514.